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Observational Study
. 2015 Dec;278(6):645-59.
doi: 10.1111/joim.12384. Epub 2015 Jun 19.

The Swedish CArdioPulmonary BioImage Study: objectives and design

G Bergström  1   2 , G Berglund  3 , A Blomberg  4 , J Brandberg  5   6 , G Engström  3 , J Engvall  7   8   9 , M Eriksson  10 , U de Faire  11   12 , A Flinck  5   6 , M G Hansson  13 , B Hedblad  3 , O Hjelmgren  1   2 , C Janson  14 , T Jernberg  12   15 , Å Johnsson  5   6 , L Johansson  16 , L Lind  17 , C-G Löfdahl  3   18 , O Melander  3   19 , C J Östgren  8 , A Persson  9   20 , M Persson  3   19 , A Sandström  21 , C Schmidt  1 , S Söderberg  21 , J Sundström  17   22 , K Toren  23 , A Waldenström  24 , H Wedel  25 , J Vikgren  5   6 , B Fagerberg  1 , A Rosengren  1
Affiliations
Observational Study

The Swedish CArdioPulmonary BioImage Study: objectives and design

G Bergström et al. J Intern Med. 2015 Dec.

Abstract

Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years. The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms. A comprehensive pilot study in 1111 individuals, which was completed in 2012, demonstrated the feasibility and financial and ethical consequences of SCAPIS. Recruitment to the national, multicentre study has recently started.

Keywords: cardiovascular; epidemiology; metabolism; pulmonary; trial design.

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Figures

Figure 1
Figure 1
Overview of the information collected from the subjects in SCAPIS. MRI, magnetic resonance imaging; CT, computed tomography; CCTA, coronary computed tomography angiography; ECG, electrocardiogram; HbA1c, glycated haemoglobin; hsCRP, high‐sensitivity C‐reactive protein.
See this image and copyright information in PMC

References

    1. Wilhelmsen L, Welin L, Svardsudd K et al Secular changes in cardiovascular risk factors and attack rate of myocardial infarction among men aged 50 in Gothenburg, Sweden. Accurate prediction using risk models. J Intern Med 2008; 263: 636–43. - PubMed
    1. Nichols M, Townsend N, Scarborough P, Rayner M. European cardiovascular disease statistics 4th edition 2012: EuroHeart II. Eur Heart J 2013; 34: 3007. - PubMed
    1. Bjorck L, Rosengren A, Bennett K, Lappas G, Capewell S. Modelling the decreasing coronary heart disease mortality in Sweden between 1986 and 2002. Eur Heart J 2009; 30: 1046–56. - PubMed
    1. Eriksson M, Holmgren L, Janlert U et al Large improvements in major cardiovascular risk factors in the population of northern Sweden: the MONICA study 1986‐2009. J Intern Med 2011; 269: 219–31. - PubMed
    1. van Lammeren GW, den Ruijter HM, Vrijenhoek JE et al Time‐dependent changes in atherosclerotic plaque composition in patients undergoing carotid surgery. Circulation 2014; 129: 2269–76. - PubMed

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