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. 2016 Jun;11(3):194-201.
doi: 10.1111/ijpo.12045. Epub 2015 Jun 19.

Associations of sedentary time patterns and TV viewing time with inflammatory and endothelial function biomarkers in children

L Gabel  1   2 , N D Ridgers  3 , P A Della Gatta  3 , L Arundell  3 , E Cerin  3 , S Robinson  3 , R M Daly  3 , D W Dunstan  4   5   6   7   8   9 , J Salmon  3
Affiliations

Associations of sedentary time patterns and TV viewing time with inflammatory and endothelial function biomarkers in children

L Gabel et al. Pediatr Obes. 2016 Jun.

Abstract

Objective: Investigate associations of TV viewing time and accelerometry-derived sedentary time with inflammatory and endothelial function biomarkers in children.

Methods: Cross-sectional analysis of 164 7-10-year-old children. TV viewing time was assessed by parental proxy report and total and patterns of sedentary time accumulation (e.g. prolonged bouts) were assessed by accelerometry. C-reactive protein (CRP), homeostasis model assessment of insulin resistance, interleukin-2, -6, -8, -10, tumour necrosis factor alpha, adiponectin, resistin, brain-derived neurotrophic factor, soluble intercellular and vascular adhesion molecule 1, plasminogen activator inhibitor 1 and soluble E-selectin were assessed. Generalised linear models assessed the associations of TV viewing and sedentary time with biomarkers, adjusting for sex, waist circumference, moderate- to vigorous-intensity physical activity and diet density.

Results: Each additional h week(-1) of TV viewing was associated with 4.4% (95% CI: 2.1, 6.7) greater CRP and 0.6% (0.2, 1.0) greater sVCAM-1 in the fully adjusted model. The association between frequency and duration of 5-10 min bouts of sedentary time and CRP was positive after adjustment for sex and waist circumference but attenuated after adjustment for diet density.

Conclusions: This study suggests that TV viewing was unfavourably associated with several markers of inflammation and endothelial dysfunction. The detrimental association between 5 and 10 min bouts of sedentary time and CRP approached significance, suggesting that further research with a stronger study design (longitudinal and/or experimental) is needed to better understand how the accumulation of sedentary time early in life may influence short and longer term health.

Keywords: Cardiometabolic; paediatric; sedentary behaviour.

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References

    1. de Ferranti SD, Gauvreau K, Ludwig DS, Neufeld EJ, Newburger JW, Rifai N. Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation 2004; 110: 2494–2497. - PubMed
    1. McMahon SK, Haynes A, Ratnam N, et al Increase in type 2 diabetes in children and adolescents in Western Australia. Med J Aust 2004; 180: 459–461. - PubMed
    1. Berenson GS, Wattigney WA, Tracy RE, et al Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons aged 6 to 30 years and studied at necropsy (The Bogalusa Heart Study). Am J Phys Anthropol 1992; 70: 851–858. - PubMed
    1. Balagopal P, de Ferranti SD, Cook S, et al Nontraditional risk factors and biomarkers for cardiovascular disease: mechanistic, research, and clinical considerations for youth: a scientific statement from the American Heart Association. Circulation 2011; 123: 2749–2769. - PubMed
    1. Canas JA, Sweeten S, Balagopal PB. Biomarkers for cardiovascular risk in children. Curr Opin Cardiol 2013; 28: 103–114. - PubMed

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