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Case Reports
. 2015 Jan-Apr;19(1):83-7.
doi: 10.4103/0973-029X.157207.

Linear IgA dermatosis adult variant with oral manifestation: A rare case report

T Isaac Joseph  1 , Pradeesh Sathyan  1 , K U Goma Kumar  1
Affiliations
Case Reports

Linear IgA dermatosis adult variant with oral manifestation: A rare case report

T Isaac Joseph et al. J Oral Maxillofac Pathol. 2015 Jan-Apr.

Abstract

Linear immunoglobulin A (IgA) dermatosis (LAD) is a rare autoimmune disorder that presents as a vesiculo-bullous lesion with cutaneous manifestations, but rare oral mucosal involvement. Here we discuss a case of a vesiculobullous lesion with severe oral and ocular mucosal involvement mimicking pemphigoid with histopathological evidence of subepithelial blisters. Direct immunofluorescence (DIF) confirmed the lesion as LAD of adult variant, although with atypical clinical features.

Keywords: Cicatricial pemphigoid; linear IgA dermatosis; vesiculobullous lesion.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Ruptured vesicle in healing phase with scar formation in the neck
Figure 2
Figure 2
Scaring of bulbar conjunctiva on the right eye
Figure 3
Figure 3
Multiple intact bullae on hard palate with erythematous irregular ulcers
Figure 4
Figure 4
(a) Generalized desquamative gingivitis involving maxilla. (b) Generalized desquamative gingivitis involving mandible
Figure 5
Figure 5
Parakeratinized stratified squamous epithelium with subepithelial split and inflammatory infiltrate in connective tissue (H&E stain, x100)
Figure 6
Figure 6
(a) Direct immunofluorescence showing linear deposition of immunoglobulin A (IgA) at the basement membrane (Direct immunofluorescence, x 100). (b) Direct immunofluorescence showing linear deposition of immunoglobulin A (IgA) at the basement membrane (Direct immunofluorescence, x 100)
Figure 7
Figure 7
Healing of oral lesion after medication
See this image and copyright information in PMC

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