Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jun 5:6:278.
doi: 10.3389/fimmu.2015.00278. eCollection 2015.

Discovery of IL-8/CXCL8 (The Story from Frederick)

Teizo Yoshimura  1
Affiliations
Review

Discovery of IL-8/CXCL8 (The Story from Frederick)

Teizo Yoshimura. Front Immunol. .
No abstract available

Keywords: IL-8; MCP-1; chemoattractants; chemokines; inflammation.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A chemotaxis assay system used to purify MDNCF. (A) Previously used individual chemotaxis chamber (left) vs. 48-multi-well chemotaxis chamber (right). (B) Consecutive fractions eluted from a reversed-phase HPLC column were assayed in duplicate at two different dilutions (1:1000 and 1:3000) in a single chamber with a negative (buffer) and positive (FMLF) control, and migrated cells on the bottom of the filter were stained (from the original notebook). The fraction 38 had the peak activity. (C) The percentage of migrated cells was analyzed using an image analyzer.
See this image and copyright information in PMC

References

    1. Altman LC. Chemotactic lymphokines: a review. In: Gallin JI, Quie G, editors. Leukocyte Chemotaxis. New York: Raven Press; (1978). p. 267–87.
    1. Merrill WW, Naegel GP, Matthay RA, Reynolds HY. Alveolar macrophage-derived chemotactic factor: kinetics of in vitro production and partial characterization. J Clin Invest (1980) 65:268–76.10.1172/JCI109668 - DOI - PMC - PubMed
    1. Granstein RD, Margolis R, Mizel SB, Sauder DN. In vivo inflammatory activity of epidermal cell-derived thymocyte activating factor and recombinant interleukin 1 in the mouse. J Clin Invest (1986) 77:1020–7.10.1172/JCI112354 - DOI - PMC - PubMed
    1. Luger TA, Charon JA, Colot M, Micksche M, Oppenheim JJ. Chemotactic properties of partially purified human epidermal cell-derived thymocyte-activating factor (ETAF) for polymorphonuclear and mononuclear cells. J Immunol (1983) 131:816–20. - PubMed
    1. Sauder DN, Mounessa NL, Katz SI, Dinarello CA, Gallin JI. Chemotactic cytokines: the role of leukocytic pyrogen and epidermal cell thymocyte-activating factor in neutrophil chemotaxis. J Immunol (1984) 132:828–32. - PubMed

LinkOut - more resources