First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex

Affiliations

¹ Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK; Department of Biomedical and Forensic Sciences, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.
² U.S. Naval Medical Research Unit No. 3 (NAMRU-3), Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana; Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
³ U.S. Naval Medical Research Unit No. 3 (NAMRU-3), Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
⁴ Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
⁵ Department of Microbiology, University of Ghana Medical School, Ghana.
⁶ Ghana Health Service, Accra, Ghana.
⁷ Disease Control Unit, Ministry of Health, Ho, Ghana.
⁸ School of Allied Health Sciences, College of Health Sciences, University of Ghana, Korle-Bu, Accra, Ghana.
⁹ Department of Microbiology, University of Ghana Medical School, Ghana; School of Allied Health Sciences, College of Health Sciences, University of Ghana, Korle-Bu, Accra, Ghana.
¹⁰ Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
¹¹ Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK. Electronic address: p.bates@lancaster.ac.uk.

PMID: 26099650
DOI: 10.1016/j.ijpara.2015.05.001

Free article

First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex

Godwin Kwakye-Nuako et al. Int J Parasitol. 2015 Sep.

Free article

. 2015 Sep;45(11):679-84.

doi: 10.1016/j.ijpara.2015.05.001. Epub 2015 Jun 19.

Affiliations

¹ Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK; Department of Biomedical and Forensic Sciences, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.
² U.S. Naval Medical Research Unit No. 3 (NAMRU-3), Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana; Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
³ U.S. Naval Medical Research Unit No. 3 (NAMRU-3), Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
⁴ Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
⁵ Department of Microbiology, University of Ghana Medical School, Ghana.
⁶ Ghana Health Service, Accra, Ghana.
⁷ Disease Control Unit, Ministry of Health, Ho, Ghana.
⁸ School of Allied Health Sciences, College of Health Sciences, University of Ghana, Korle-Bu, Accra, Ghana.
⁹ Department of Microbiology, University of Ghana Medical School, Ghana; School of Allied Health Sciences, College of Health Sciences, University of Ghana, Korle-Bu, Accra, Ghana.
¹⁰ Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
¹¹ Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK. Electronic address: p.bates@lancaster.ac.uk.

PMID: 26099650
DOI: 10.1016/j.ijpara.2015.05.001

Abstract

An active case detection approach with PCR diagnosis was used in the Ho District of the Volta Region, Ghana that identified individuals with active cutaneous leishmaniasis. Three isolates were successfully cultured and DNA sequences from these were analysed (ribosomal RNA internal transcribed spacer 1; ribosomal protein L23a intergenic spacer; RNA polymerase II large subunit), showing them to be Leishmania, identical to each other but different from all other known Leishmania spp. Phylogenetic analysis showed the parasites to be new members of the Leishmania enriettii complex, which is emerging as a possible new subgenus of Leishmania parasites containing human pathogens.

Keywords: Cutaneous leishmaniasis; Ghana; Leishmania; Phylogeny.

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090678/Z/09/Z/Wellcome Trust/United Kingdom

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First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex

Affiliations

First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex

Authors

Affiliations

Abstract

Publication types

MeSH terms

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Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous