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. 2015 Sep;59(9):5827-9.
doi: 10.1128/AAC.00978-15. Epub 2015 Jun 22.

In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species

Magdalena Skóra  1 , Małgorzata Bulanda  2 , Tomasz Jagielski  3
Affiliations

In vitro activities of a wide panel of antifungal drugs against various Scopulariopsis and Microascus species

Magdalena Skóra et al. Antimicrob Agents Chemother. 2015 Sep.

Abstract

The in vitro activities of 11 antifungal drugs against 68 Scopulariopsis and Microascus strains were investigated. Amphotericin B, 5-fluorocytosine, fluconazole, itraconazole, ketoconazole, miconazole, posaconazole, voriconazole, and ciclopirox showed no or poor antifungal effect. The best activities were exhibited by terbinafine and caspofungin, where the MIC and MEC (minimal effective concentration) ranges were 0.0313 to >16 μg/ml and 0.125 to 16 μg/ml, respectively. The MIC and MEC modes were both 1 µg/ml for terbinafine and caspofungin; the MIC50 and MEC50 were 1 µg/ml for both drugs, whereas the MIC90 and MEC90 were 4 µg/ml and 16 µg/ml, respectively.

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