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. 2016 Aug;18(8):658-65.
doi: 10.1177/1098612X15592343. Epub 2015 Jun 22.

Serum and urinary cystatin C in cats with feline immunodeficiency virus infection and cats with hyperthyroidism

Liesbeth F E Ghys  1 , Dominique Paepe  2 , Elien R L Taffin  2 , Eva Vandermeulen  3 , Luc Duchateau  4 , Pascale M Y Smets  2 , Joris Delanghe  5 , Sylvie Daminet  2
Affiliations

Serum and urinary cystatin C in cats with feline immunodeficiency virus infection and cats with hyperthyroidism

Liesbeth F E Ghys et al. J Feline Med Surg. 2016 Aug.

Abstract

Objectives: The objective of this study was to investigate serum cystatin C (sCysC) and urinary cystatin C (uCysC) in cats with hyperthyroidism and cats with feline immunodeficiency virus (FIV).

Methods: Thirty cats with FIV, 26 hyperthyroid cats and 28 healthy cats were included. sCysC and uCysC:creatinine (uCysC/uCr) ratio were measured with a human particle-enhanced nephelometric immunoassay, previously validated for feline CysC measurement. Routine renal variables (serum creatinine [sCr], urine specific gravity, urinary protein:creatinine ratio [UPC]) were also measured in the three groups.

Results: Cats with hyperthyroidism had significantly higher sCysC and higher uCysC/uCr ratio, lower sCr and a higher UPC than healthy cats. Cats with FIV infection did not show a significantly higher sCysC concentration but had a significantly higher sCr and UPC than healthy cats. uCysC could be detected in only four of them.

Conclusions and relevance: This study demonstrated that sCysC is increased in cats with hyperthyroidism, in contrast with sCr, but not in cats with FIV. Many hyperthyroid cats, but only four cats with FIV, had an elevated uCysC/uCr ratio. Further studies may reveal if uCysC might be a valuable marker for tubular dysfunction in cats.

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Conflict of interest statement

The authors do not have any potential conflicts of interest to declare.

Figures

Figure 1
Figure 1
Box plot of serum cystatin C (sCysC) (mg/l) for cats with hyperthyroidism (HyperT4; n = 26), feline immunodeficiency virus (FIV; n = 30) and healthy cats (healthy; n = 28). This displays an outlying value
Figure 2
Figure 2
Box plot of the urinary cystatin C/urinary creatinine ratio (uCysC/uCr ratio) for cats with hyperthyroidism (HyperT4; n = 26), feline immunodeficiency virus (FIV; n = 30) and healthy cats (healthy; n = 28)
See this image and copyright information in PMC

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