Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2015 Aug;66(2):275-7.
doi: 10.1161/HYPERTENSIONAHA.115.05277. Epub 2015 Jun 22.

New clues towards solving the mystery of endothelin and blood pressure regulation

Joshua S Speed  1 , David M Pollock  2
Affiliations
Editorial

New clues towards solving the mystery of endothelin and blood pressure regulation

Joshua S Speed et al. Hypertension. 2015 Aug.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Hypothetical schematic of vascular endothelial derived ET-1 overproduction influence on blood pressure. Overexpression of endothelial derived ET-1 reduces both ETA and ETB receptor expression on systemic vasculature, yet maintains normal vessel reactivity to ET-1. In contrast, upregulation of ETA and ETB receptors occurs in renal tissue, although the specific cell type is not known. Given the large amount of receptor expressed in renal tubular epithelium, the increase in receptor expression in the kidney could be a compensatory mechanism for the increase in blood pressure since renal tubular ET-1 promotes natriuresis. In addition to renal and vascular ET-1 receptors, evidence suggests that ETA and ETB receptors on peripheral nerves may modulate blood pressure, but this mechanism is very poorly understood in terms of blood pressure regulation and how vascular endothelium may or may not impact nervous system ETA and ETB receptor activity is unknown.
See this image and copyright information in PMC

Comment on

References

    1. Kohan DE, Rossi NF, Inscho EW, Pollock DM. Regulation of blood pressure and salt homeostasis by endothelin. Physiol Rev. 2011;91:1–77. - PMC - PubMed
    1. Kisanuki YY, Emoto N, Ohuchi T, Widyantoro B, Yagi K, Nakayama K, Kedzierski RM, Hammer RE, Yanagisawa H, Williams SC, Richardson JA, Suzuki T, Yanagisawa M. Low blood pressure in endothelial cell-specific endothelin 1 knockout mice. Hypertension. 2010;56:121–128. - PubMed
    1. Rautureau Y, Coelo SC, Fraulob-Aquino JC, Huo G, Rehman A, Offermanns S, Paradis P, Schiffrin EL. Hypertension. in press; 2015. Inducible human endothelin-1 overexpression in endothelium raises blood pressure via endothelin type A receptors. - PubMed
    1. Heiden S, Vignon-Zellweger N, Masuda S, Yagi K, Nakayama K, Yanagisawa M, Emoto N. Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice. PLoS One. 2014;9:e88730. - PMC - PubMed
    1. Amiri F, Virdis A, Neves MF, Iglarz M, Seidah NG, Touyz RM, Reudelhuber TL, Schiffrin EL. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation. 2004;110:2233–2240. - PubMed

LinkOut - more resources