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Review
. 2015 Mar-Apr;31(2):471-6.
doi: 10.12669/pjms.312.6592.

Steroid-induced ischemic bone necrosis of femoral head: Treatment strategies

Bin Wu  1 , Zhong Dong  2 , Shuyuan Li  3 , Hongmei Song  4
Affiliations
Review

Steroid-induced ischemic bone necrosis of femoral head: Treatment strategies

Bin Wu et al. Pak J Med Sci. 2015 Mar-Apr.

Abstract

Fat hypertrophy, intravascular coagulation, and fat emboli are important risk factors of steroid-induced ischemic bone necrosis (SI-IBN) which may develop during the initial one year after commencing the use of steroids. This pathology is best studied by MRI, particularly for its staging. The cautious strategies such as low dose, oral route, short duration of steroid usage, use of steroid sparing agent, and alcohol avoidance should be followed as a traditional therapy. The objective of this review article was to recognize and evaluate various Treatment strategies for steroid-induced ischemic bone necrosis of femoral head.

Literature search: Various electronic databases including PubMed, Google and Cochrane library were comprehensively searched for articles on steroid-induced ischemic bone necrosis of femoral head and its treatment strategies. Ninety four articles were reviewed, examined and importantly appraised and the most appropriate 32 papers were used to write this review article.

Conclusion: Bisphosphonates, alendronate, and hyperbaric oxygen (HBO) treatments have been reported to be effective against IBN. To recommend the regular use of bisphosphonate in IBN patients, more evidences with a larger number of patients are required to verify its therapeutic effectiveness. Core decompression, osteotomy, bone graft and tantalum rod are the surgical approaches for the management of IBN. Advance form of IBN (bone tissue collapse) is advised to be treated with arthroplasty which should be durable, particularly in young patients.

Keywords: Arthoplasty; Bone collapse; Ischemic bone necrosis; Steroid; Vasculature.

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Figures

Fig.1
Fig.1
Graphical illustration of the development of steroid-induced ischemic bone necrosis of femoral head.
Fig.2
Fig.2
Ficat classification of ischemic bone necrosis of femoral head.
See this image and copyright information in PMC

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