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. 2015 May;7(5):908-11.
doi: 10.3978/j.issn.2072-1439.2015.04.60.

Inflammatory myofibroblastic tumour of the lung: a reactive lesion or a true neoplasm?

Nikolaos Panagiotopoulos  1 , Davide Patrini  1 , Lasha Gvinianidze  1 , Wen Ling Woo  1 , Elaine Borg  1 , David Lawrence  1
Affiliations

Inflammatory myofibroblastic tumour of the lung: a reactive lesion or a true neoplasm?

Nikolaos Panagiotopoulos et al. J Thorac Dis. 2015 May.

Abstract

Inflammatory myofibroblastic tumour (IMT) of the lung represents an extremely rare type of inflammatory pseudo tumor that appears most commonly in children and young individuals. There has been an ongoing controversy whether an IMT is a reactive lesion or a true neoplasm making the further management extremely challenging. Purpose of the paper is through a literature review to highlight the existence of this rare tumour along with its key features and the management options available.

Keywords: Lung neoplasms; inflammatory myofibroblastic tumors (IMTs).

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Figures

Figure 1
Figure 1
Chest X-ray (CXR) showing a solitary left upper lobe lung mass.
Figure 2
Figure 2
MRI scan demonstrating a lesion in the left upper lobe of the lung. MRI, magnetic resonance imaging.
Figure 3
Figure 3
CT scan depicting a white colour mass in the left lung. CT, computed tomography.
Figure 4
Figure 4
PET CT shows FDG avid lesion in the left upper lobe of the lung. CT, computed tomography; PET, positron emission tomography; FDG, fluorodeoxyglucose.
Figure 5
Figure 5
A low power image of the tumor which comprises interlacing fascicles of bland spindle cells which obliterate the underlying architecture of the lung (H&E ×20 magnification).
Figure 6
Figure 6
Spindle cell component that is admixed with inflammatory cells including plasma cells and eosinophils. The spindle cells show minimal pleomorphism and mitotic figures which are sparse (H&E ×200 magnification).
Figure 7
Figure 7
Spindle cell component that is admixed with inflammatory cells including plasma cells and eosinophils. The spindle cells show minimal pleomorphism and mitotic figures which are sparse (H&E ×200 magnification).
See this image and copyright information in PMC

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