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. 2015 Oct;44(5):296-300.
doi: 10.1111/jmp.12179. Epub 2015 Jun 22.

Development of SHIVs with circulating, transmitted HIV-1 variants

Amit Sharma  1 , David F Boyd  1   2 , Julie Overbaugh  1
Affiliations

Development of SHIVs with circulating, transmitted HIV-1 variants

Amit Sharma et al. J Med Primatol. 2015 Oct.

Abstract

SHIV/macaque model is critical for pre-clinical HIV-1 research. The ability of this model to predict efficacious intervention(s) in humans depends on how faithfully the model recapitulates key features of HIV-1 transmission and pathogenesis. Here, we provide insights for rationally designing SHIVs with transmitted HIV-1 variants for vaccine and prevention research.

Keywords: HIV-1 envelope; SHIV/macaque model; transmitted/founder HIV-1.

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