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Randomized Controlled Trial
. 2015 Dec 1;70(4):377-85.
doi: 10.1097/QAI.0000000000000732.

Cost-Effectiveness of Collaborative Care for Depression in HIV Clinics

Jacob T Painter  1 , John C Fortney, Allen L Gifford, David Rimland, Thomas Monson, Maria C Rodriguez-Barradas, Jeffrey M Pyne
Affiliations
Randomized Controlled Trial

Cost-Effectiveness of Collaborative Care for Depression in HIV Clinics

Jacob T Painter et al. J Acquir Immune Defic Syndr. .

Abstract

Objective: To examine the cost-effectiveness of the HIV Translating Initiatives for Depression Into Effective Solutions (HITIDES) intervention.

Design: Randomized controlled effectiveness and implementation trial comparing depression collaborative care with enhanced usual care.

Setting: Three Veterans Health Administration HIV clinics in the Southern United States.

Subjects: Two hundred forty-nine HIV-infected patients completed the baseline interview; 123 were randomized to the intervention and 126 to usual care.

Intervention: HITIDES consisted of an offsite HIV depression care team that delivered up to 12 months of collaborative care. The intervention used a stepped-care model for depression treatment, and specific recommendations were based on the Texas Medication Algorithm Project and the VA/Department of Defense Depression Treatment Guidelines.

Main outcome measures: Quality-adjusted life years (QALYs) were calculated using the 12-Item Short Form Health Survey, the Quality of Well Being Scale, and by converting depression-free days to QALYs. The base case analysis used outpatient, pharmacy, patient, and intervention costs. Cost-effectiveness was calculated using incremental cost-effectiveness ratios (ICERs) and net health benefit. ICER distributions were generated using nonparametric bootstrap with replacement sampling.

Results: The HITIDES intervention was more effective and cost saving compared with usual care in 78% of bootstrapped samples. The intervention net health benefit was positive and therefore deemed cost-effective using an ICER threshold of $50,000/QALY.

Conclusions: In HIV clinic settings, this intervention was more effective and cost saving compared with usual care. Implementation of offsite depression collaborative care programs in specialty care settings may be a strategy that not only improves outcomes for patients but also maximizes the efficient use of limited health care resources.

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Conflict of interest statement

Conflicts of Interest: no potential conflicts of interest

Figures

Figure 1
Figure 1
ICER of Bootstrap Distribution for Base Case (DFD-derived QALYs; Outpatient and Pharmacy costs)
Figure 2
Figure 2
Acceptability Curves for all QALY Measures (Bootstrapped Sample)
See this image and copyright information in PMC

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