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. 2015 Jul 2;17(13):3338-41.
doi: 10.1021/acs.orglett.5b01560. Epub 2015 Jun 23.

Copper-/Silver-Mediated Arylation of C(sp(2))-H Bonds with 2-Thiophenecarboxylic Acids

Sheng Zhao  1 , Yue-Jin Liu  1 , Sheng-Yi Yan  1 , Fa-Jie Chen  1 , Zhuo-Zhuo Zhang  1 , Bing-Feng Shi  1
Affiliations

Copper-/Silver-Mediated Arylation of C(sp(2))-H Bonds with 2-Thiophenecarboxylic Acids

Sheng Zhao et al. Org Lett. .

Abstract

A copper/silver-mediated arylation of (hetero)aryl C-H bonds with 2-thiophenecarboxylic acids has been achieved. The protocol features a broad substrate scope and high functional group tolerance. Preliminary mechanistic studies indicate that a cascade protodecarboxylation/dehydrogenative coupling process is likely involved.

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