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Case Reports
. 2015 Jun 24:9:148.
doi: 10.1186/s13256-015-0619-3.

Improved antioxidant status by omega-3 fatty acid supplementation in breast cancer patients undergoing chemotherapy: a case series

Prakash Mansara  1 , Mrunal Ketkar  2 , Rashmi Deshpande  3 , Amol Chaudhary  4 , Kavita Shinde  5 , Ruchika Kaul-Ghanekar  6
Affiliations
Case Reports

Improved antioxidant status by omega-3 fatty acid supplementation in breast cancer patients undergoing chemotherapy: a case series

Prakash Mansara et al. J Med Case Rep. .

Abstract

Introduction: Breast cancer is the second leading cause of cancer death in women worldwide and the third most common cancer in India. Various studies have reported that chemotherapy reduces the antioxidant status in patients with cancer. A diet rich in omega-3 fatty acids has been shown to offer protection against breast cancer through various mechanisms. However, there are no reports suggesting a relationship between consumption of omega-3 fatty acids during chemotherapy and antioxidant status in patients with breast cancer. Thus, the objective of this study was to evaluate whether fish oil supplementation could improve the antioxidant status of five women with breast cancer undergoing chemotherapy.

Case presentation: We report on the cases of five Indian women with breast cancer, in the age group of 34 to 60 years, who had poorly differentiated breast carcinoma and underwent modified radical mastectomy. Postsurgery, the patients were given fish oil capsules containing eicosapentaenoic acid (180 mg) and docosahexaenoic acid (120 mg)/capsule during their chemotherapy. Informed consent was obtained from each participant and they were followed-up to the completion of six chemotherapy cycles at 21-day intervals.

Conclusions: The supplementation of fish oil significantly (p < 0.01) increased superoxide dismutases, glutathione reductase and catalase activity in red blood cells as well as the total plasma antioxidant status in the patients. This approach of using omega-3 fatty acids as an adjuvant treatment for breast cancer may help oncologists to manage the side effects of ongoing chemotherapy by improving the antioxidant status in patients.

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Figures

Fig. 1
Fig. 1
Fish oil supplementation improves the antioxidant status in five patients with breast cancer. Superoxide dismutase (SOD) (a), catalase (CAT) (b) and glutathione reductase (GRx) (c) activities in red blood cells and plasma antioxidant status (d) in the patients before and after chemotherapy and fish oil supplementation (Chemo + FO) have been shown. The results have been presented as mean ± standard deviation. **p < 0.01 indicates statistically significant difference in the results before and after fish oil intervention. ORAC oxygen radical absorbance capacity
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