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. 2015 Jun 24:14:60.
doi: 10.1186/s12944-015-0056-8.

Low density lipoprotein cholesterol control status among Canadians at risk for cardiovascular disease: findings from the Canadian Primary Care Sentinel Surveillance Network Database

Erfan Aref-Eshghi  1 , Jason Leung  2 , Marshall Godwin  3 , Pauline Duke  4 , Tyler Williamson  5 , Masoud Mahdavian  6 , Shabnam Asghari  7   8
Affiliations

Low density lipoprotein cholesterol control status among Canadians at risk for cardiovascular disease: findings from the Canadian Primary Care Sentinel Surveillance Network Database

Erfan Aref-Eshghi et al. Lipids Health Dis. .

Abstract

Background: To determine the prevalence of uncontrolled LDL-C in patients with high cardiovascular disease (CVD) risks across Canada and to examine its related factors.

Methods: Non-pregnant adults >20 years-old, who had a lipid test completed between January 1, 2009 and December 31, 2011 and were included in the Canadian Primary Care Surveillance Network (CPCSSN) database were studied. The Framingham-Risk-Score was calculated to determine the risk levels. A serum LDL-C level of >2.0 mmol/L was considered as being poorly controlled. Patients with a previous record of a cerebrovascular accident, peripheral artery disease, or an ischemic heart disease were regarded as those under secondary prevention. Logistic regression modeling was performed to examine the factors associated with the LDL-C control.

Results: A total of 6,405 high-risk patients were included in the study and, of this population, 68% had a suboptimal LDL-C, which was significantly associated with the female gender (OR: 3.26; 95% CI: 2.63-4.05, p < 0.0001) and no medication therapy (OR: 6.31, 95% CI: 5.21-7.65, p < 0.0001). Those with comorbidities of diabetes, hypertension, obesity, and smokers had a better LDL-C control. Rural residents (OR: 0.64, 95% CI: 0.52-0.78, p < 0.0001), and those under secondary prevention (OR: 0.42; 95 % CI: 0.35-0.51, p < 0.0001), were also more likely to have a better LDL-C control.

Conclusion: A high proportion of high-cardiac risk patients in Canadian primary care settings have suboptimal LDL-C control. A lack of medication therapy appears to be the major contributing factor to this situation.

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Figures

Fig. 1
Fig. 1
The flowchart of the study
See this image and copyright information in PMC

References

    1. World Health Organization . Global status report on noncommunicable diseases 2010. 2011.
    1. Public Health Agency of Canada. Canadian Institute for Health Information. Heart and Stroke Foundation of Canada. Statistics Canada . Tracking heart disease and stroke in Canada. 2009.
    1. Musunuru K. Atherogenic dyslipidemia: cardiovascular risk and dietary intervention. Lipids. 2010;45(10):907–14. doi: 10.1007/s11745-010-3408-1. - DOI - PMC - PubMed
    1. Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A, et al. 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult–2009 recommendations. Can J Cardiol. 2009;25(10):567–79. doi: 10.1016/S0828-282X(09)70715-9. - DOI - PMC - PubMed
    1. Leon AS, Sanchez OA. Response of blood lipids to exercise training alone or combined with dietary intervention. Med Sci Sports Exerc. 2001;33(6 Suppl):S502–15. doi: 10.1097/00005768-200106001-00021. - DOI - PubMed

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