PP050. NT-Pro-BNP: Correlation with adverse outcome markers in hypertensive gestational syndromes

Abstract

Introduction: Brain-type natriuretic peptide is released by cardiomyocites in response to parietal stress augmentation and systemic endothelial dysfunction. Hypertensive Gestational Syndromes (HGS) share this mechanism, but the correlation between NT-Pro-BNP and maternal/fetal outcomes is not yet clear enough.

Objectives: Evaluate the correlation between NT-Pro-BNP in HGS and Normotensive Pregnant Women (NPW), with clinical and biological markers of adverse maternal/fetal outcome.

Methods: We performed a transversal case-control study to analyze NT-Pro-BNP and established markers in 87 patients with HGS and 95 NPW.

Results: The average gestational age at delivery (GAD) was: HGS 35.5 weeks, NPW 38.1 weeks; birth average weight (BAW): HGS 2616.2 gr, NPW 3281.6 gr; average maternal age (AMA): HGS 33.7 years, NPW 33.5 years; media NT-Pro-BNP (pg/ml): HGS 626.5, NPW 60.6. In the HGS media NT-Pro-BNP (pg/ml): HELLP 1342.3, Preeclampsia 686.7, Gestational hypertension 171.1, Chronic hypertension 108.5, the following significant correlations were found for NT-Pro-BNP relation to: Proteinuria p0.001, GOT p0.001, GPT p0.001, Platelets p0.001, Hematocrit p0.026,Uric acid p0.001, Alkaline phosphatase p0.001, LDH p0.001, GAD p0.004, BAW p0.010, AMA p0.042, cardiac failure p0.002, number of used anti-hypertensive drugs p0.004.

Conclusions: NT-Pro-BNP significantly correlates with markers of adverse maternal/fetal outcome in HGS and identify a high risk subgroup in these Syndromes.