Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2015 Jun 23;6(3):e00716.
doi: 10.1128/mBio.00716-15.

Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers

David S Fedson  1 , Jeffrey R Jacobson  2 , Ole Martin Rordam  3 , Steven M Opal  4
Affiliations
Observational Study

Treating the Host Response to Ebola Virus Disease with Generic Statins and Angiotensin Receptor Blockers

David S Fedson et al. mBio. .

Abstract

Treatments targeting the Ebola virus may eventually be shown to work, but they will not have an impact on overall Ebola mortality in West Africa. Endothelial dysfunction is responsible for the fluid and electrolyte imbalances seen in Ebola patients. Because inexpensive generic statins and angiotensin receptor blockers restore endothelial barrier integrity, they can be used to treat the host response in these patients. In Sierra Leone, approximately 100 Ebola patients were treated with this combination, and reports indicate that survival was greatly improved.

PubMed Disclaimer

Comment in

References

    1. Wong G, Qiu X, Olinger GG, Kobinger GP. 2014. Post-exposure therapy of filovirus infections. Trends Microbiol 22:456–463. doi:10.1016/j.tim.2014.04.002. - DOI - PubMed
    1. Kreuels B, Wichmann D, Emmerich P, Schmidt-Chanasit J, de Heer G, Kluge S, Sow A, Renné T, Günther S, Lohse AW, Addo MM, Schmiedel S. 2014. A case of severe Ebola virus infection complicated by gram-negative septicemia. N Engl J Med 371:2394–2401. doi:10.1056/NEJMoa1411677. - DOI - PubMed
    1. Lyon GM, Mehta AK, Varkey JB, Brantly K, Plyler L, McElroy AK, Kraft CS, Towner JS, Spiropoulou C, Ströher U, Uyeki TM, Ribner BS, Emory Serious Communicable Diseases Unit . 2014. Clinical care of two patients with Ebola virus disease in the United States. N Engl J Med 371:2402–2409. doi:10.1056/NEJMoa1409838. - DOI - PubMed
    1. Wolf T, Kann G, Becker S, Stephan C, Brodt HR, de Leuw P, Grünewald T, Vogl T, Kempf VA, Keppler OT, Zacharowski K. 2015. Severe Ebola virus disease with vascular leakage and multiorgan failure: treatment of a patient in intensive care. Lancet 385:1428–1435. doi:10.1016/S0140-6736(14)62384-9. - DOI - PubMed
    1. Feldmann H, Geisbert TW. 2011. Ebola haemorrhagic fever. Lancet 377:849–862. doi:10.1016/S0140-6736(10)60667-8. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources