Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Jul;64(7):2329-31.
doi: 10.2337/db15-0436.

An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes

Wilfredo Rosario  1 , David D'Alessio  2
Affiliations
Comment

An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes

Wilfredo Rosario et al. Diabetes. 2015 Jul.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic of the intestinal mucosa showing the normal state with intact GLP-1 signaling (A) and the consequences of impaired GLP-1 action on IELs (depicted as blue cells with purple nuclei) (B). GLP-1 stimulation of IELs promotes barrier function and normal microbial interaction and mutes inflammation. Loss of this activity has the potential to cause abnormalities in mucosal function.
See this image and copyright information in PMC

Comment on

References

    1. Kieffer TJ, Habener JF. The glucagon-like peptides. Endocr Rev 1999;20:876–913 - PubMed
    1. Schirra J, Katschinski M, Weidmann C, et al. . Gastric emptying and release of incretin hormones after glucose ingestion in humans. J Clin Invest 1996;97:92–103 - PMC - PubMed
    1. Barrera JG, Sandoval DA, D’Alessio DA, Seeley RJ. GLP-1 and energy balance: an integrated model of short-term and long-term control. Nat Rev Endocrinol 2011;7:507–516 - PMC - PubMed
    1. Holst JJ, Deacon CF. Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors. Diabetologia 2005;48:612–615 - PubMed
    1. D’Alessio DA. What if gut hormones aren’t really hormones: DPP-4 inhibition and local action of GLP-1 in the gastrointestinal tract. Endocrinology 2011;152:2925–2926 - PMC - PubMed

Substances