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Comment
. 2015 Jul;64(7):2335-7.
doi: 10.2337/db15-0434.

Evidence for Residual and Partly Reparable Insulin Secretory Function and Maintained β-Cell Gene Expression in Islets From Patients With Type 1 Diabetes

Leslie S Satin  1 , Santiago Schnell  2
Affiliations
Comment

Evidence for Residual and Partly Reparable Insulin Secretory Function and Maintained β-Cell Gene Expression in Islets From Patients With Type 1 Diabetes

Leslie S Satin et al. Diabetes. 2015 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Schematic representation of results obtained by Krogvold et al. (10). Islets were isolated from control and T1D human subjects for analysis. In vitro measurements of glucose-induced insulin secretion revealed residual secretion at low levels in most T1D islets vs. control islets, but secretion was improved after several days in tissue culture under euglycemic conditions. RNA analysis revealed retention of key β-cell genes involved in insulin secretion but reduced expression of these genes in T1D islets. Gs, the alpha subunit of Gs; STX1A, Syntaxin-1A.
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