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Review
. 2015:2015:382918.
doi: 10.1155/2015/382918. Epub 2015 May 27.

Uric Acid as a Marker of Kidney Disease: Review of the Current Literature

Christin Giordano  1 , Olga Karasik  1 , Kelli King-Morris  2 , Abdo Asmar  2
Affiliations
Review

Uric Acid as a Marker of Kidney Disease: Review of the Current Literature

Christin Giordano et al. Dis Markers. 2015.

Abstract

Uric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove. We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric acid as a marker for future renal decline. After review, we conclude that uric acid is definitively linked to the development of chronic kidney disease and can be a poor prognostic factor for the development of acute renal failure, as well. However, further human research is needed before predictive models utilizing uric acid can be developed and used in the clinical setting.

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References

    1. Johnson R. J., Lanaspa M. A., Gaucher E. A. Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations. Seminars in Nephrology. 2011;31(5):394–399. doi: 10.1016/j.semnephrol.2011.08.002. - DOI - PMC - PubMed
    1. Ryu E.-S., Kim M. J., Shin H.-S., et al. Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease. American Journal of Physiology: Renal Physiology. 2013;304(5):F471–F480. doi: 10.1152/ajprenal.00560.2012. - DOI - PubMed
    1. Verzola D., Ratto E., Villaggio B., et al. Uric acid promotes apoptosis in human proximal tubule cells by oxidative stress and activation of NAPDH oxidase NOX 4. PLoS ONE. 2014;9(12) doi: 10.1371/journal.pone.0115210.e115210 - DOI - PMC - PubMed
    1. Sánchez-Lozada L. G., Tapia E., Santamaría J., et al. Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats. Kidney International. 2005;67(1):237–247. doi: 10.1111/j.1523-1755.2005.00074.x. - DOI - PubMed
    1. Kanbay M., Yilmaz M. I., Sonmez A., et al. Serum uric acid level and endothelial dysfunction in patients with nondiabetic chronic kidney disease. American Journal of Nephrology. 2011;33(4):298–304. doi: 10.1159/000324847. - DOI - PMC - PubMed

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