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Review
. 2015:2015:415648.
doi: 10.1155/2015/415648. Epub 2015 May 25.

Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin for Helicobacter pylori Infection: A Systematic Review and Meta-Analysis

Xiaoqun Liu  1 , Hui Wang  1 , Zhifa Lv  1 , Youhua Wang  1 , Ben Wang  1 , Yong Xie  1 , Xiaojiang Zhou  1 , Nonghua Lv  1
Affiliations
Review

Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin for Helicobacter pylori Infection: A Systematic Review and Meta-Analysis

Xiaoqun Liu et al. Gastroenterol Res Pract. 2015.

Abstract

Background. To conduct a systematic review and meta-analysis of clinical trials for eradication of Helicobacter pylori (H. pylori) that included a treatment arm with a proton pump inhibitor, rifabutin, and amoxicillin. Materials and Methods. We selected clinical trials that examined the efficacy of H. pylori eradication therapies and included a study arm using the test regimen from major medical literature databases and abstracts from major gastroenterology meetings. We also did subgroup and sensitivity analyses. Results. Twenty-one studies were included in systematic review. The total eradication rates of the test regimen were 70.4% by intent-to-treat (ITT) and 72.0% by per-protocol (PP) analyses. The pooled odds ratio (OR) was 0.55 using fixed effects model (P = 0.283) for the test regimen versus other triple regimens. The total eradication rates were 68.4% for the test regimen and 81.9% in the control group by ITT, while the OR was 1.08 using random effects model (P = 0.019). The pooled eradication rate was 66.4% for the test regimen and 67.4% for the control group by ITT. The total adverse effects incidence were 25.1% for the test regimen. Conclusions. The test regimen for H. pylori rescue therapy may be not superior to control regimens in efficacy.

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Figures

Figure 1
Figure 1
Flow diagram of trials identified and selected.
Figure 2
Figure 2
Triple regimens with PPI, amoxicillin, and rifabutin compared with other triple regimens.
Figure 3
Figure 3
Triple regimens with PPI amoxicillin rifabutin compared with quadruple regimens.
Figure 4
Figure 4
Total adverse effects.
Figure 5
Figure 5
The funnel plot of triple regimen containing amoxicillin and rifabutin compared with other triple regimens.
Figure 6
Figure 6
The funnel plot of triple regimens containing amoxicillin and rifabutin compared with quadruple regimens.
See this image and copyright information in PMC

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