Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015:2015:354158.
doi: 10.1155/2015/354158. Epub 2015 May 27.

Synchronous Multicentric Giant Cell Tumour of Distal Radius and Sacrum with Pulmonary Metastases

Varun Sharma Tandra  1 , Krishna Mohan Reddy Kotha  1 , Moorthy Gadisetti Venkata Satyanarayana  1 , Kali Varaprasad Vadlamani  1 , Vyjayanthi Yerravalli  1
Affiliations

Synchronous Multicentric Giant Cell Tumour of Distal Radius and Sacrum with Pulmonary Metastases

Varun Sharma Tandra et al. Case Rep Oncol Med. 2015.

Abstract

Giant cell tumour (GCT) is an uncommon primary bone tumour, and its multicentric presentation is exceedingly rare. We report a case of a 45-year-old female who presented to us with GCT of left distal radius. On the skeletal survey, osteolytic lesion was noted in her right sacral ala. Biopsy confirmed both lesions as GCT. Pulmonary metastasis was also present. Resection-reconstruction arthroplasty for distal radius and thorough curettage and bone grafting of the sacral lesion were done. Multicentric GCT involving distal radius and sacrum with primary sacral involvement is not reported so far to our knowledge.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a and b) Preop plain radiograph of left wrist showing expansile solitary lytic lesion involving left distal radius; (c and d) postoperative radiographs after resection and reconstruction arthroplasty of left wrist; (e) radiographs of her left wrist showing wrist subluxation following k-wire removal; (f) 1 year follow-up radiograph of her left wrist with gross subluxation of wrist.
Figure 2
Figure 2
(a) Radiograph of the pelvis AP view; (b) 3D reconstruction and (c) axial section of CT showing expansile lytic lesion involving the right sacral ala with cortical break and surrounding soft-tissue component extending into right SI joint space and pelvis measuring 5.2 × 5.7 × 6.3 cm eroding the adjacent iliac bone. Mass extending into the sacral canal. (d) MRI showing large expansile heterogeneous lobulated lesion with few septations involving right sacroiliac joint. Predominantly lytic lesion with cortical destruction features suggestive of GCT.
Figure 3
Figure 3
Multiple irregular opacities in apical segments of right upper lobe and left lingular superior segment, anterobasal and posterobasal segments suggestive of metastasis.
Figure 4
Figure 4
(a) Intraoperative photograph of curettage and bone grafting of the sacral lesion; (b) histopathology slide showing characteristic osteoclast like giant cells (arrows) in the background of mononuclear cells.
See this image and copyright information in PMC

References

    1. Eckardt J. J., Grogan T. J. Giant cell tumor of bone. Clinical Orthopaedics and Related Research. 1986;204:45–58. - PubMed
    1. Hoch B., Inwards C., Sundaram M., Rosenberg A. E. Multicentric giant cell tumor of bone: clinicopathologic analysis of thirty cases. The Journal of Bone and Joint Surgery—Series A. 2006;88(9):1998–2008. doi: 10.2106/jbjs.e.01111. - DOI - PubMed
    1. Balke M., Henrichs M. P., Gosheger G., et al. Giant cell tumors of the axial skeleton. Sarcoma. 2012;2012:10. doi: 10.1155/2012/410973.410973 - DOI - PMC - PubMed
    1. Dhillon M. S., Prasad P. Multicentric giant cell tumour of bone. Acta Orthopaedica Belgica. 2007;73(3):289–299. - PubMed
    1. Park I.-H., Jeon I.-H. Multicentric giant cell tumor of bone: ten lesions at presentation. Skeletal Radiology. 2003;32(9):526–529. doi: 10.1007/s00256-003-0658-5. - DOI - PubMed

LinkOut - more resources