Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2015 Jun 25:5:11715.
doi: 10.1038/srep11715.

Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis

Qianqian Liu  1 , Xiaoqing Li  2 , Wenzhang Li  3 , Xinmiao Du  4 , Jian-Qing He  4 , Chuanmin Tao  1 , Yulin Feng  4
Affiliations
Meta-Analysis

Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis

Qianqian Liu et al. Sci Rep. .

Abstract

Treatment of infectious diseases caused by the carbapenem-resistant Pseudomonas aeruginosa (CRPA) is becoming more challenging with each passing year. We conducted a meta-analysis to assess the impact of carbapenem resistance on mortality of patients with P. aeruginosa infection. We searched PUBMED, Web of science, EMBASE, Google Scholar and the Cochrane Library up to December 25, 2014, to identify published cohort or case-control studies. 17 studies, including 6660 patients carrying P. aeruginosa, were identified. The pooling analysis indicated that patients infected with CRPA had significantly higher mortality than those infected with carbapenem-susceptible P. aeruginosa (CSPA) (crude OR = 1.64; 95%CI = 1.40, 1.93; adjusted OR = 2.38; 95%CI = 1.53, 3.69). The elevated risk of mortality in patients with CRPA infection was not lessened when stratified by study design, sites of infection, or type of carbapenem, except that the estimate effect vanished in CRPA high-incidence region, South America (crude OR = 1.12; 95%CI = 0.64, 1.99). Begg's (z = 0.95, p = 0.34) and Egger's test (t = 1.23, p = 0.24) showed no evidence of publication bias. Our results suggest that carbapenem resistance may increase the mortality of patients with P. aeruginosa infection, whether under univariate or multivariate analysis.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Flow diagram of included studies.
Figure 2
Figure 2. Crude odds ratio (OR) for the association between carbapenem resistance and mortality of patients with Pseudomonas aeruginosa infection.
Figure 3
Figure 3. Sensitivity analysis of Crude odds ratio (OR) for the association between carbapenem resistance and mortality of patients with Pseudomonas aeruginosa infection.
Figure 4
Figure 4. The funnel plot for selected studies on Crude odds ratio (OR) for the association between carbapenem resistance and mortality of patients with Pseudomonas aeruginosa infection.
Figure 5
Figure 5. Adjusted odds ratio (OR) for the association between carbapenem resistance and mortality of patients with Pseudomonas aeruginosa infection.
Figure 6
Figure 6. Sensitivity analysis of adjusted odds ratio (OR) for the association between carbapenem resistance and mortality of patients with Pseudomonas aeruginosa infection.
See this image and copyright information in PMC

References

    1. Blanc D. S., Francioli P. & Zanetti G. Molecular Epidemiology of Pseudomonas aeruginosa in the Intensive Care Units - A Review. Open Microbiol J 1, 8–11 10.2174/1874285800701010008 (2007). - DOI - PMC - PubMed
    1. Bassetti M., Righi E. & Viscoli C. Pseudomonas aeruginosa serious infections: mono or combination antimicrobial therapy? Curr Med Chem 15, 517–522 (2008). - PubMed
    1. Maschmeyer G. & Braveny I. Review of the incidence and prognosis of Pseudomonas aeruginosa infections in cancer patients in the 1990s. Eur J Clin Microbiol Infect Dis 19, 915–925 (2000). - PubMed
    1. Todeschini G. et al. Improved prognosis of Pseudomonas aeruginosa bacteremia in 127 consecutive neutropenic patients with hematologic malignancies. Int J Infect Dis 3, 99–104 (1998). - PubMed
    1. Gaynes R., Edwards J. R. & National Nosocomial Infections Surveillance S. Overview of nosocomial infections caused by gram-negative bacilli. Clin Infect Dis 41, 848–854 10.1086/432803 (2005). - DOI - PubMed

Publication types

MeSH terms