Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jul;15(7):452-63.
doi: 10.1038/nri3858.

Genetic susceptibility to invasive Salmonella disease

James J Gilchrist  1 , Calman A MacLennan  2 , Adrian V S Hill  3
Affiliations
Review

Genetic susceptibility to invasive Salmonella disease

James J Gilchrist et al. Nat Rev Immunol. 2015 Jul.

Erratum in

  • Nat Rev Immunol. 2015 Oct;15(10):663

Abstract

Invasive Salmonella disease, in the form of enteric fever and invasive non-typhoidal Salmonella (iNTS) disease, causes substantial morbidity and mortality in children and adults in the developing world. The study of genetic variations in humans and mice that influence susceptibility of the host to Salmonella infection provides important insights into immunity to Salmonella. In this Review, we discuss data that have helped to elucidate the host genetic determinants of human enteric fever and iNTS disease, alongside data from the mouse model of Salmonella infection. Considered together, these studies provide a detailed picture of the immunobiology of human invasive Salmonella disease.

PubMed Disclaimer

References

    1. J Infect Dis. 2004 Nov 15;190(10):1755-7 - PubMed
    1. J Exp Med. 2006 Jul 10;203(7):1745-59 - PubMed
    1. Curr Opin HIV AIDS. 2010 Mar;5(2):173-8 - PubMed
    1. J Immunol. 2004 Apr 1;172(7):4463-9 - PubMed
    1. Microb Pathog. 1991 Jul;11(1):33-8 - PubMed

LinkOut - more resources