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. 2016 Aug;14 Suppl 1(Suppl 1):136-46.
doi: 10.1111/vco.12158. Epub 2015 Jun 25.

Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012)

S A Collette  1   2 , S D Allstadt  3   4 , E M Chon  5 , W Vernau  6 , A N Smith  7 , L D Garrett  8 , K Choy  9   10 , R B Rebhun  3 , C O Rodriguez Jr  3 , K A Skorupski  3
Affiliations

Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012)

S A Collette et al. Vet Comp Oncol. 2016 Aug.

Abstract

CHOP-based (cyclophosphamide, doxorubicin, vinca alkaloid, prednisolone) chemotherapy protocols are often recommended for treatment of feline lymphoma. While maintenance-free CHOP-based protocols have been published and readily used in dogs, there is limited literature regarding similar maintenance-free protocols in cats. The purpose of this study was to describe the outcome of cats with intermediate- to high-grade lymphoma that were prescribed a modified 25-week University of Wisconsin-Madison (UW-25) chemotherapy protocol. A secondary objective was examination of potential prognostic factors. One hundred and nineteen cats from five institutions treated with a UW-25-based protocol were included. The Kaplan-Meier median progression-free interval (PFI) and survival time (MST) were 56 and 97 (range 2-2019) days, respectively. Cats assessed as having a complete response (CR) to therapy had significantly longer PFI and MST than those with partial or no response (PFI 205 versus 54 versus 21 days, respectively, P < 0.0001 and MST 318 versus 85 versus 27 days, respectively, P < 0.0001).

Keywords: CHOP; cat; feline; lymphoma; maintenance-free chemotherapy; survival.

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Conflict of interest statement

None of the authors of this paper have financial or personal relationship with other people or organizations that could inappropriately influence or bias the content of this paper.

Figures

Figure 1
Figure 1
Kaplan–Meier curve showing PFI of 119 cats with intermediate to high-grade lymphoma treated with a modified UW-25 protocol. Median PFI was 56 days.
Figure 2
Figure 2
Kaplan–Meier curve showing overall survival of 119 cats with intermediate-to high-grade lymphoma treated with a modified UW-25 protocol. Median survival time was 97 days.
Figure 3
Figure 3
Kaplan–Meier curve showing PFI of 119 cats with intermediate- to high-grade lymphoma stratified according to response to therapy. The median PFI for cats achieving a CR was 205 days, compared with 54 days for those achieving a PR and 21 days for those with NR to therapy.
Figure 4
Figure 4
Kaplan–Meier curve showing survival of 119 cats with intermediate- to high-grade lymphoma stratified according to response to therapy. The median survival time for cats achieving a CR was 318 days, compared with 85 days for those achieving a PR and 27 days for those with NR to therapy.
See this image and copyright information in PMC

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