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. 2015 Jun 21;21(23):7313-9.
doi: 10.3748/wjg.v21.i23.7313.

Increased risk of second malignancy in pancreatic intraductal papillary mucinous tumors: Review of the literature

Gian Luca Baiocchi  1 , Sarah Molfino  1 , Barbara Frittoli  1 , Graziella Pigozzi  1 , Federico Gheza  1 , Giacomo Gaverini  1 , Antonio Tarasconi  1 , Chiara Ricci  1 , Francesco Bertagna  1 , Luigi Grazioli  1 , Guido A M Tiberio  1 , Nazario Portolani  1
Affiliations

Increased risk of second malignancy in pancreatic intraductal papillary mucinous tumors: Review of the literature

Gian Luca Baiocchi et al. World J Gastroenterol. .

Abstract

Aim: To analyze the available evidence about the risk of extrapancreatic malignancies and pancreatic ductal adenocarcinoma associated to pancreatic intraductal papillary mucinous tumors (IPMNs).

Methods: A systematic search of literature was undertaken using MEDLINE, EMBASE, Cochrane and Web-of-Science libraries. No limitations for year of publication were considered; preference was given to English papers. All references in selected articles were further screened for additional publications. Both clinical series and Literature reviews were selected. For all eligible studies, a standard data extraction form was filled in and the following data were extracted: study design, number of patients, prevalence of pancreatic cancer and extrapancreatic malignancies in IPMN patients and control groups, if available.

Results: A total of 805 abstracts were selected and read; 25 articles were considered pertinent and 17 were chosen for the present systematic review. Eleven monocentric series, 1 multicentric series, 1 case-control study, 1 population-based study and 3 case report were included. A total of 2881 patients were globally analyzed as study group, and the incidence of pancreatic cancer and/or extrapancreatic malignancies ranged from 5% to 52%, with a mean of 28.71%. When a control group was analyzed (6 papers), the same incidence was as low as 9.4%.

Conclusion: The available Literature is unanimous in claiming IPMNs to be strongly associated with pancreatic and extrapancreatic malignancies. The consequences in IPMNs management are herein discussed.

Keywords: 18FDG-PET; Computed tomography scan; Diagnosis; Follow-up; Intraductal papillary mucinous neoplasm; Pancreas; Tumors.

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Figures

Figure 1
Figure 1
Articles retrieval strategy, according to the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. IPMN: Intraductal papillary mucinous tumor.
See this image and copyright information in PMC

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