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Review
. 2015 Jun 23;6(2):353-71.
doi: 10.3390/genes6020353.

The Fork in the Road: Histone Partitioning During DNA Replication

Anthony T Annunziato  1
Affiliations
Review

The Fork in the Road: Histone Partitioning During DNA Replication

Anthony T Annunziato. Genes (Basel). .

Abstract

In the following discussion the distribution of histones at the replication fork is examined, with specific attention paid to the question of H3/H4 tetramer "splitting." After a presentation of early experiments surrounding this topic, more recent contributions are detailed. The implications of these findings with respect to the transmission of histone modifications and epigenetic models are also addressed.

Keywords: acetylation; chromatin; epigenetics; histone; methylation; nucleosome; replication; splitting; tetramer.

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