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. 2015 Jun 25;10(6):e0131649.
doi: 10.1371/journal.pone.0131649. eCollection 2015.

Mitochondrial DNA copy number in peripheral blood and melanoma risk

Jie Shen  1 , Vancheswaran Gopalakrishnan  1 , Jeffrey E Lee  2 , Shenying Fang  2 , Hua Zhao  1
Affiliations

Mitochondrial DNA copy number in peripheral blood and melanoma risk

Jie Shen et al. PLoS One. .

Abstract

Mitochondrial DNA (mtDNA) copy number in peripheral blood has been suggested as risk modifier in various types of cancer. However, its influence on melanoma risk is unclear. We evaluated the association between mtDNA copy number in peripheral blood and melanoma risk in 500 melanoma cases and 500 healthy controls from an ongoing melanoma study. The mtDNA copy number was measured using real-time polymerase chain reaction. Overall, mean mtDNA copy number was significantly higher in cases than in controls (1.15 vs 0.99, P<0.001). Increased mtDNA copy number was associated with a 1.45-fold increased risk of melanoma (95% confidence interval: 1.12-1.97). Significant joint effects between mtDNA copy number and variables related to pigmentation and history of sunlight exposure were observed. This study supports an association between increased mtDNA copy number and melanoma risk that is independent on the known melanoma risk factors (pigmentation and history of sunlight exposure).

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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References

    1. Forsea AM, Del Marmol V, Stratigos A, Geller AC. Melanoma Prognosis in Europe: Far from Equal. The British journal of dermatology. 2014. 10.1111/bjd.12923 . - DOI - PubMed
    1. Erdmann F, Lortet-Tieulent J, Schuz J, Zeeb H, Greinert R, Breitbart EW, et al. International trends in the incidence of malignant melanoma 1953-2008—are recent generations at higher or lower risk? International journal of cancer Journal international du cancer. 2013;132(2):385–400. 10.1002/ijc.27616 . - DOI - PubMed
    1. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095–128. 10.1016/S0140-6736(12)61728-0 . - DOI - PMC - PubMed
    1. Lucas RM, McMichael AJ, Armstrong BK, Smith WT. Estimating the global disease burden due to ultraviolet radiation exposure. International journal of epidemiology. 2008;37(3):654–67. 10.1093/ije/dyn017 . - DOI - PubMed
    1. Mayer JE, Swetter SM, Fu T, Geller AC. Screening, early detection, education, and trends for melanoma: current status (2007–2013) and future directions: Part II. Screening, education, and future directions. J Am Acad Dermatol. 2014;71(4):611 e1–e10; quiz 21–2. 10.1016/j.jaad.2014.05.045 . - DOI - PubMed

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