Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Dec;63(6):667-70.
doi: 10.1093/bja/63.6.667.

Pharmacokinetics of propofol in young children after a single dose

C Saint-Maurice  1 , I D Cockshott, E J Douglas, M O Richard, J L Harmey
Affiliations
Free article

Pharmacokinetics of propofol in young children after a single dose

C Saint-Maurice et al. Br J Anaesth. 1989 Dec.
Free article

Abstract

The pharmacokinetics of propofol were studied following a single bolus injection (2.5 mg kg-1) in 10 healthy children (4-7 yr). Propofol was distributed rapidly and extensively (Vss 10.9 (1.2) litre kg-1) and cleared rapidly from the body (Cl 30.6 (2.9) ml min-1 kg-1). With the exception of a larger central compartment volume (V alpha 722 (113) ml kg-1), these data are similar to those reported for young adults who received an identical dose and who underwent sampling over the same period. The larger value of V alpha is consistent with the higher induction dose requirement reported for children.

PubMed Disclaimer

LinkOut - more resources