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. 2015 Jun 23;20(6):11554-68.
doi: 10.3390/molecules200611554.

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols

Ana L Legarda-Ceballos  1 , Esther del Olmo  2 , Julio López-Abán  3 , Ricardo Escarcena  4 , Luis A Bustos  5 , Cristina Fonseca-Berzal  6 , Alicia Gómez-Barrio  7 , Juan C Dib  8 , Arturo San Feliciano  9 , Antonio Muro  10
Affiliations

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols

Ana L Legarda-Ceballos et al. Molecules. .

Abstract

Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0-6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.

Keywords: Trypanosoma cruzi; amastigotes; aminoalcohols; cytotoxicity; diamines; epimastigotes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Summary of the synthetic procedure for obtaining type I compounds 1–13 and type II ones 14–21.
Figure 1
Figure 1
General structure of compounds type I and II.
See this image and copyright information in PMC

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