Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jun 23;20(6):11554-68.
doi: 10.3390/molecules200611554.

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols

Ana L Legarda-Ceballos  1 , Esther del Olmo  2 , Julio López-Abán  3 , Ricardo Escarcena  4 , Luis A Bustos  5 , Cristina Fonseca-Berzal  6 , Alicia Gómez-Barrio  7 , Juan C Dib  8 , Arturo San Feliciano  9 , Antonio Muro  10
Affiliations

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols

Ana L Legarda-Ceballos et al. Molecules. .

Abstract

Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0-6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.

Keywords: Trypanosoma cruzi; amastigotes; aminoalcohols; cytotoxicity; diamines; epimastigotes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Summary of the synthetic procedure for obtaining type I compounds 1–13 and type II ones 14–21.
Figure 1
Figure 1
General structure of compounds type I and II.
See this image and copyright information in PMC

References

    1. Coura J.R., Viñas P.A. Chagas disease: A new worldwide challenge. Nature. 2010;465:S6–S7. doi: 10.1038/nature09221. - DOI - PubMed
    1. Teixeira D.E., Benchimol M., Crepaldi P.H., de Souza W. Interactive multimedia to teach the life cycle of Trypanosoma cruzi, the causative agent of Chagas disease. PLoS Negl. Trop. Dis. 2012;6:e1749. doi: 10.1371/journal.pntd.0001749. - DOI - PMC - PubMed
    1. World Health Organization (WHO): Geneva, Switzerland, Fact Sheet No 340. [(accessed on 16 April 2015)]. Available online: http:// www.who.int/mediacentre/factsheets/fs340/en/
    1. Rassi A., Rassi A., Marin-Neto J.A. Chagas disease. Lancet. 2010;375:1388–1402. doi: 10.1016/S0140-6736(10)60061-X. - DOI - PubMed
    1. Pérez-Molina J.A., Rodríguez-Guardado A., Soriano A., Pinazo M.J., Carrilero B., García-Rodríguez M., Salas J., Torrús D., Soler-Ferrer C., Puente S., et al. Guidelines on the treatment of chronic coinfection by Trypanosoma cruzi and HIV outside endemic areas. HIV Clin. Trials. 2011;12:287–298. doi: 10.1310/hct1206-287. - DOI - PubMed

Publication types

LinkOut - more resources