Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul 5;128(13):1724-7.
doi: 10.4103/0366-6999.159342.

High-frequency Oscillations and the Seizure Onset Zones in Neocortical Epilepsy

Yan-Ping Sun, Yu-Ping Wang  1 , Zhi-Hong Wang, Feng-Yu Wu, Li-Ou Tang, Shou-Wen Zhang, Hai-Tao Pei, Yan Wang, Zhao-Yang Huang, Qing Xue, Cui-Ping Xu, Jun-Li Tai
Affiliations

High-frequency Oscillations and the Seizure Onset Zones in Neocortical Epilepsy

Yan-Ping Sun et al. Chin Med J (Engl). .

Abstract

Background: To study the characters of high-frequency oscillations (HFOs) in the seizure onset zones (SOZ) and the nonseizure onset zones (NSOZ) in the electrocorticography (ECoG) of patients with neocortical epilepsy.

Methods: Only patients with neocortical epilepsy who were seizure-free after surgery as determined with ECoG were included. We selected patients with normal magnetic resonance imaging before surgery in order to avoid the influence of HFOs by other lesions. Three minutes preictal and 10 min interictal ECoG as recorded in 39 channels in the SOZ and 256 channels in the NSOZ were analyzed. Ripples and fast ripples (FRs) were analyzed by Advanced Source Analysis software (ASA, The Netherlands). Average duration of HFOs was analyzed in SOZ and NSOZ separately.

Results: For ripples, the permillage time occupied by HFOs was 0.83 in NSOZ and 1.17 in SOZ during the interictal period. During preictal period, they were 2.02 in NSOZ and 7.93 in SOZ. For FRs, the permillage time occupied by HFOs was 0.02 in NSOZ and 0.42 in SOZ during the interictal period. During preictal period, they were 0.03 in NSOZ and 2 in SOZ.

Conclusions: High-frequency oscillations are linked to SOZ in neocortical epilepsy. Our study demonstrates the prevalent occurrence of HFOs in SOZ. More and more burst of HFOs, especially FRs, means the onset of seizures.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Ripple (a) and fast ripple (b) analyzed by Advanced Source Analysis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Zijlmans M, Jacobs J, Kahn YU, Zelmann R, Dubeau F, Gotman J. Ictal and interictal high frequency oscillations in patients with focal epilepsy. Clin Neurophysiol. 2011;122:664–71. - PMC - PubMed
    1. Jefferys JG, Menendez de la Prida L, Wendling F, Bragin A, Avoli M, Timofeev I, et al. Mechanisms of physiological and epileptic HFO generation. Prog Neurobiol. 2012;98:250–64. - PMC - PubMed
    1. Jacobs J, Zelmann R, Jirsch J, Chander R, Dubeau CE, Gotman J. High frequency oscillations (80-500 Hz) in the preictal period in patients with focal seizures. Epilepsia. 2009;50:1780–92. - PMC - PubMed
    1. Engel J, Jr, Wilson C, Bragin A. Advances in understanding the process of epileptogenesis based on patient material: What can the patient tell us? Epilepsia. 2003;44 Suppl 12:60–71. - PubMed
    1. Frost JD, Jr, Lee CL, Le JT, Hrachovy RA, Swann JW. Interictal high frequency oscillations in an animal model of infantile spasms. Neurobiol Dis. 2012;46:377–88. - PMC - PubMed

Publication types