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Meta-Analysis
. 2015 Jun 26:15:58.
doi: 10.1186/s12872-015-0044-y.

Rs7193343 polymorphism in zinc finger homeobox 3 (ZFHX3) gene and atrial fibrillation: an updated meta-analysis of 10 case-control comparisons

ChuanNan Zhai  1   2   3 , HongLiang Cong  4 , YuJie Liu  5 , Ying Zhang  6 , XianFeng Liu  7   8 , Hao Zhang  9   10 , ZhiJing Ren  11   12
Affiliations
Meta-Analysis

Rs7193343 polymorphism in zinc finger homeobox 3 (ZFHX3) gene and atrial fibrillation: an updated meta-analysis of 10 case-control comparisons

ChuanNan Zhai et al. BMC Cardiovasc Disord. .

Abstract

Background: The previous genome-wide studies have shown that rs7193343 single-nucleotide polymorphism (SNP) in zinc finger homeobox 3 (ZFHX3) gene correlate with risk of atrial fibrillation (AF). However, the distribution of this SNP differs significantly among various populations. The present study was to investigate whether combined evidence shows the association between ZFHX3 rs7193343 SNP and the risk of AF in various populations.

Methods: A systematic search of all studies published through Dec 2014 was conducted using the Medline, Embase, WanFang, ScienceDirect, CNKI, and OVID databases. The case-control studies that evaluated an association between rs7193343 SNP and risk of AF were identified. The association between the ZFHX3 rs7193343 SNP and AF susceptibility was assessed using genetic models.

Results: We collected 10 comparisons from six studies for rs7193343 SNP, including 1037 cases and 4310 controls in Asian, 5583 cases and 38215 controls in Caucasian, and then performed an updated meta-analysis and subgroup analysis based on ethnicity. In overall population, the occurrence of AF was found to be associated with T-allelic of rs7193343 SNP in ZFHX3 (OR =1.17, 95% CI 1.10-1.26). In subgroup analysis, we observed there was significant association between T-allele of rs7193343 and risk of AF in Caucasian subgroups (OR =1.20, 95% CI 1.12-1.30), but no statistically significance (OR = 1.07, 95% CI 0.92-1.24) in Asian population.

Conclusion: In Caucasian population, genetic variant rs7193343 SNP is associated with risk of AF in Caucasian population. However, no association is found in Asian population based on the current evidence. Further studies with larger sample size involving case-control populations with multiple ethnics are still required in the future.

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Figures

Fig. 1
Fig. 1
Flow of studies through the meta-analysis
Fig. 2
Fig. 2
ORs and 95 %CI of individual studies and pooled data for overall study of the association between the ZFHX3 rs7193343 T-allele and AF
Fig. 3
Fig. 3
ORs and 95 %CI of individual studies and pooled data for stratification study of the association between the ZFHX3 rs7193343 T-allele and AF
Fig. 4
Fig. 4
Funnel plot of studies for the association between the ZFHX3 rs7193343 T-allele and AF in all subjects (Begg rank correlation test, P = 0.47)
Fig. 5
Fig. 5
Funnel plot of studies for the association between the ZFHX3 rs7193343 T-allele and AF in all subjects (Egger weighted regression test, P = 0.76)
See this image and copyright information in PMC

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