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. 1989 Nov;64(5):463-7.
doi: 10.1111/j.1464-410x.1989.tb05277.x.

Possible role of Tamm-Horsfall glycoprotein in calcium oxalate crystallisation

T Yoshioka  1 , T Koide, M Utsunomiya, H Itatani, T Oka, T Sonoda
Affiliations

Possible role of Tamm-Horsfall glycoprotein in calcium oxalate crystallisation

T Yoshioka et al. Br J Urol. 1989 Nov.

Abstract

The role of Tamm-Horsfall glycoprotein (THGP) in the crystallisation of calcium oxalate was investigated. The results showed THGP to have a weak inhibitory effect on crystal growth. In contrast, urinary macromolecules showed a strong inhibitory effect. THGP should, therefore, not be considered the main component of urinary macromolecules which have a strong inhibitory effect on crystal growth. However, THGP did enhance crystal production in the early phase of crystallisation. It appears that THGP should be viewed as a promoter rather than an inhibitor of calcium oxalate crystallisation at physiological concentrations.

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