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Observational Study
. 2015;10(7):1145-54.
doi: 10.2217/fmb.15.41. Epub 2015 Jun 29.

Clinical experience with the use of daptomycin in a tertiary care teaching hospital in Barcelona, Spain

Nancy Sandoval  1 , Santiago Grau  2   3 , Luisa Sorlí  1 , Milagro Montero  1 , Erika Esteve  1 , Juan Pablo Horcajada  1
Affiliations
Observational Study

Clinical experience with the use of daptomycin in a tertiary care teaching hospital in Barcelona, Spain

Nancy Sandoval et al. Future Microbiol. 2015.

Abstract

Aim: We reviewed the clinical use of daptomycin in daily practice.

Materials & methods: Efficacy and safety were assessed in 175 consecutive patients given daptomycin for at least 72 h.

Results: Daptomycin was given as rescue treatment in 50.9% of cases. Bloodstream infection (34.8%) and skin/soft-tissue infection (19.4%) were the most frequent. In 62.3% of patients, the dose of ≤ 6 mg/kg/day was administered. Staphylococcus spp. were isolated in 52.6% of cases (MRSA in 9.5%, CoNS in 34.3%) and Enterococcus spp. in 8.7%. Clinical success was 75% and microbiological eradication 48.6%. Two patients discontinued daptomycin due to hemolytic anemia of unlikely and possible relationship with daptomycin, respectively.

Conclusion: Daptomycin was effective and well tolerated in patients with severe Gram-positive infections.

Keywords: Gram-positive infections; bacteremia; clinical outcome; daptomycin; retrospective study.

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Comment in

  • Daptomycin use: where is the truth? Authors' response.
    Echeverría-Esnal D, Grau S, Horcajada JP. Echeverría-Esnal D, et al. Future Microbiol. 2017 Jan;12:13-14. doi: 10.2217/fmb-2016-0199. Epub 2016 Dec 6. Future Microbiol. 2017. PMID: 27922754 No abstract available.
  • Daptomycin use: where is the truth?
    Aubin GG, Deschanvres C, Boutoille D, Abgueguen P, Corvec S, Caillon J, Lepelletier D, Moal F, Navas D. Aubin GG, et al. Future Microbiol. 2017 Jan;12:9-12. doi: 10.2217/fmb-2016-0142. Epub 2016 Dec 12. Future Microbiol. 2017. PMID: 27936929 No abstract available.

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