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Meta-Analysis
. 2015 Jun 29;10(6):e0131689.
doi: 10.1371/journal.pone.0131689. eCollection 2015.

Expression of Notch1 Correlates with Breast Cancer Progression and Prognosis

Xun Yuan  1 , Mingsheng Zhang  1 , Hua Wu  1 , Hanxiao Xu  1 , Na Han  1 , Qian Chu  1 , Shiying Yu  1 , Yuan Chen  1 , Kongming Wu  1
Affiliations
Meta-Analysis

Expression of Notch1 Correlates with Breast Cancer Progression and Prognosis

Xun Yuan et al. PLoS One. .

Abstract

Various studies have evaluated the significance of Notch1 expression in breast cancer, but the results have ever been disputed. By using 21 studies involving 3867 patients, this meta-analysis revealed that the expression of Notch1 was significantly higher in breast cancer than in normal tissues (OR=7.21; 95%CI, 4.7-11.07) and that higher Notch1 expression was associated with transition from ductal carcinoma in situ (DCIS) to invasive cancer (OR=3.75; 95% CI, 1.8-7.78). Higher Notch1 activity was observed in the basal subtype of breast cancer (OR=2.53; 95% CI, 1.18-5.43). Moreover, patients with Notch1 overexpression exhibited significantly worse overall and recurrence-free survival. Our meta-analysis suggests that Notch inhibitors may be useful in blocking the early progression of DCIS and that the outcomes of clinical trials for Notch1-targeting therapeutics could be improved by the molecular stratification of breast cancer patients.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of article selection.
Fig 2
Fig 2. Correlation between Notch1 expression and breast cancer development and progression as evaluated by the odds ratio (OR).
A. Association between Notch1 and breast cancer risks compared with normal breast tissues. B. Association between Notch1 and invasive ductal cancer risk compared with DCIS. C. Association between Notch1 and lymphatic metastasis. D. Association between Notch1 and tumor grade. E. Association between Notch1 and clinical stages (tumor size).
Fig 3
Fig 3. Notch1 expression levels with respect to molecular subtypes.
A. Association between Notch1 and ER-negative breast cancer risk compared with ER-positive breast cancer and normal breast tissues. B. Association between Notch1 and PR-negative breast cancer risk compared with PR-positive breast cancer and normal breast tissues. C. Association between Notch1 and the basal subtype of breast cancer relative to luminal breast cancer. D. Association between Notch1 and Her2-positive breast cancer.
Fig 4
Fig 4. Elevated Notch1 protein abundance correlates with poor prognosis.
A. Association between Notch1 and breast cancer OS. B. Association between Notch1 and breast cancer RFS. C. Association between Notch1 and MFS.
Fig 5
Fig 5. Correlation of Notch1 mRNA expression with breast cancer survival.
A. RFS rate with respect to Notch1 expression was analyzed in 508 patients (GSE25066) with breast cancer. B. OS rate with respect to Notch1 expression analyzed in 327 patients (GSE20685) with breast cancer. C. MFS rate with respect to Notch1 expression was analyzed in 200 patients (GSE11121) with breast cancer.
See this image and copyright information in PMC

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