How cells coordinate waste removal through their major proteolytic pathways
- PMID: 26123109
- DOI: 10.1038/ncb3198
How cells coordinate waste removal through their major proteolytic pathways
Abstract
The eukaryotic cell uses two complex machineries to degrade unwanted proteins. The first is the ubiquitin-proteasome system and the second is autophagy. A new study contributes to our understanding of how the two systems interconnect to coordinate protein degradation.
Comment on
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Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.Nat Cell Biol. 2015 Jul;17(7):917-29. doi: 10.1038/ncb3177. Epub 2015 Jun 15. Nat Cell Biol. 2015. PMID: 26075355 Free PMC article.
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