Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Jul;17(7):843-5.
doi: 10.1038/ncb3197.

Rubicon swaps autophagy for LAP

Keith B Boyle  1 , Felix Randow  2
Affiliations
Comment

Rubicon swaps autophagy for LAP

Keith B Boyle et al. Nat Cell Biol. 2015 Jul.

Abstract

Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP). Light has now been shed on the molecular requirements of LAP, establishing a central role for the protein Rubicon in the immune response to Aspergillus fumigatus.

PubMed Disclaimer

Comment on

References

    1. Cell Host Microbe. 2012 Mar 15;11(3):264-76 - PubMed
    1. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6226-31 - PubMed
    1. Immunity. 2014 Jun 19;40(6):924-35 - PubMed
    1. Nat Cell Biol. 2009 Apr;11(4):385-96 - PubMed
    1. Autophagy. 2015;11(1):88-99 - PubMed

Substances

LinkOut - more resources