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Review
. 2015 Jul;123(3):405-12.
doi: 10.1007/s11060-015-1849-3. Epub 2015 Jun 30.

The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression

Alfred P See  1 , Jonathon J Parker, Allen Waziri
Affiliations
Review

The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression

Alfred P See et al. J Neurooncol. 2015 Jul.

Abstract

Cell-mediated suppression of anti-tumor immunity is multifactorial in patients with cancer, and recent studies have focused on several distinct cellular agents that are associated with this phenomenon. This review will focus on the potential role of regulatory T cells (Tregs) and microglia in the suppression of cellular immunity observed in patients with glioblastoma. We discuss the ontogeny, basic biology, evidence for activity, and potential clinical options for targeting Tregs and microglia as part of immunotherapy in affected patients.

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References

    1. Nature. 2008 May 8;453(7192):236-40 - PubMed
    1. Clin Cancer Res. 2005 Dec 1;11(23 ):8304-11 - PubMed
    1. J Immunol. 2001 Mar 15;166(6):3789-96 - PubMed
    1. Clin Cancer Res. 2008 Dec 15;14(24):8270-8 - PubMed
    1. Clin Cancer Res. 2012 Nov 15;18(22):6110-21 - PubMed

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