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Multicenter Study
. 2015:16:61.
doi: 10.1186/s10194-015-0542-4. Epub 2015 Jun 30.

Non-invasive vagus nerve stimulation for acute treatment of high-frequency and chronic migraine: an open-label study

Piero Barbanti  1 , Licia Grazzi, Gabriella Egeo, Anna Maria Padovan, Eric Liebler, Gennaro Bussone
Affiliations
Multicenter Study

Non-invasive vagus nerve stimulation for acute treatment of high-frequency and chronic migraine: an open-label study

Piero Barbanti et al. J Headache Pain. 2015.

Abstract

Background: The treatment of migraine headache is challenging given the lack of a standardized approach to care, unsatisfactory response rates, and medication overuse. Neuromodulation therapy has gained interest as an alternative to pharmacologic therapy for primary headache disorders. This study investigated the effects of non-invasive vagus nerve stimulation (nVNS) in patients with high-frequency episodic migraine (HFEM) and chronic migraine (CM).

Findings: In this open-label, single-arm, multicenter study, patients with HFEM or CM self-treated up to 3 consecutive mild or moderate migraine attacks that occurred during a 2-week period by delivering two 120-s doses of nVNS at 3-min intervals to the right cervical branch of the vagus nerve. Of the 50 migraineurs enrolled (CM/HFEM: 36/14), 48 treated 131 attacks. The proportion of patients reporting pain relief, defined as a ≥50% reduction in visual analog scale (VAS) score, was 56.3% at 1 h and 64.6% at 2 h. Of these patients, 35.4% and 39.6% achieved pain-free status (VAS = 0) at 1 and 2 h, respectively. When all attacks (N = 131) were considered, the pain-relief rate was 38.2% at 1 h and 51.1% at 2 h, whereas the pain-free rate was 17.6% at 1 h and 22.9% at 2 h. Treatment with nVNS was safe and well tolerated.

Conclusion: Non-invasive vagus nerve stimulation may be effective as acute treatment for HFEM or CM and may help to reduce medication overuse and medication-associated adverse events.

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Figures

Fig. 1
Fig. 1
Response to nVNS treatment in 48 Migraineurs. Abbreviations: nVNS, non-invasive vagus nerve stimulation
Fig. 2
Fig. 2
Response to nVNS treatment in 131 Migraine Attacks. Abbreviations: nVNS, non-invasive vagus nerve stimulation
Fig. 3
Fig. 3
Response to nVNSat 1 and 2 Hours by Patient Type
Fig. 4
Fig. 4
Response to nVNSat 1 and 2 Hours by Migraine Attack Type
See this image and copyright information in PMC

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