Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1989 Dec;149(3):162-3.
doi: 10.1007/BF01958270.

Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia during L-asparaginase therapy

T Hanada  1 , Y Horigome, M Inudoh, H Takita
Affiliations
Case Reports

Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia during L-asparaginase therapy

T Hanada et al. Eur J Pediatr. 1989 Dec.

Abstract

We report a child with acute lymphocytic leukaemia who developed simultaneous osteonecrosis of vertebrae and cerebral thrombosis during L-asparaginase therapy. Fibrinogen, antithrombin III and plasminogen were decreased. Fresh frozen plasma in addition to antithrombin III concentrates were used to replenish these haemostatic proteins. L-asparaginase induced coagulopathy may cause osteonecrosis.

PubMed Disclaimer

References

    1. Cancer. 1985 Feb 15;55(4):702-6 - PubMed
    1. J Bone Joint Surg Br. 1977 Aug;59(3):308-17 - PubMed
    1. N Engl J Med. 1986 Sep 11;315(11):657-63 - PubMed
    1. Am J Pediatr Hematol Oncol. 1987 Summer;9(2):143-5 - PubMed
    1. Eur J Pediatr. 1982 Sep;139(1):48-51 - PubMed

Publication types

MeSH terms