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Review
. 2015 Nov;70(11):1092-4.
doi: 10.1136/thoraxjnl-2015-207035. Epub 2015 Jun 30.

'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung

Yina Du  1 , Minzhe Guo  2 , Jeffrey A Whitsett  1 , Yan Xu  3
Affiliations
Review

'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung

Yina Du et al. Thorax. 2015 Nov.

Abstract

We developed LungGENS (Lung Gene Expression iN Single-cell), a web-based bioinformatics resource for querying single-cell gene expression databases by entering a gene symbol or a list of genes or selecting a cell type of their interest. Gene query provides quantitative RNA expression of the gene of interest in each lung cell type. Cell type query returns associated selective gene signatures and genes encoding cell surface markers and transcription factors in interactive heatmap and tables. LungGENS will be broadly applicable in respiratory research, providing a cell-specific RNA expression resource at single-cell resolution. LungGENS is freely available for non-commercial use at https://research.cchmc.org/pbge/lunggens/default.html.

Keywords: Airway Epithelium; Surfactant protein; Systemic disease and lungs; TTF-1.

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Figures

Figure 1
Figure 1
LungGENS (Lung Gene Expression iN Single-cell) provides two main queries: ‘Query by gene’ and ‘Query by cell type’.
See this image and copyright information in PMC

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