Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Apr;13(4):195-202.

Granulocyte colony-stimulating factor and reproductive medicine: A review

Marcelo Borges Cavalcante  1 , Fabrício DA Silva Costa  2 , Ricardo Barini  3 , E Araujo Júnior  4
Affiliations
Review

Granulocyte colony-stimulating factor and reproductive medicine: A review

Marcelo Borges Cavalcante et al. Iran J Reprod Med. 2015 Apr.

Abstract

Background: Recently, the use of granulocyte colony-stimulating factor (G-CSF) has been proposed to improve pregnancy outcomes in reproductive medicine.

Objective: A systematic review of the current use of G-CSF in patients who have difficulty conceiving and maintaining pregnancy was performed.

Materials and methods: Two electronic databases (PubMed/ Medline and Scopus) were searched. Study selection, data extraction and quality assessment were performed in duplicate. The subject codes used were granulocyte colony-stimulating factor, G-CSF, recurrent miscarriage, IVF failure, and endometrium.

Results: The search of electronic databases resulted in 215 citations (PubMed/ Medline: 139 and Scopus: 76), of which 38 were present in both databases. Of the remaining 177 publications, seven studies were included in the present review.

Conclusion: Treatment with G-CSF is a novel proposal for immune therapy in patients with recurrent miscarriage and implantation failure following cycles of IVF. However, a larger number of well-designed studies are required for this treatment to be established.

Keywords: Granulocyte colony-stimulating factor; Immunotherapy; Recurrent miscarriage; Reproductive medicine; Review.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flowchart outlining the database search
See this image and copyright information in PMC

References

    1. Rai R, Regan L. Recurrent miscarriage. Lancet. 2006;368:601–611. - PubMed
    1. Practice Committee of the American Society for Reproductive Medicine. Definitions of Infertility and Recurrent Pregnancy Loss: a committee opinion. Fertil Steril. 2013;99:63. - PubMed
    1. Allison JL, Schust DJ. Recurrent first trimester pregnancy loss: revised definitions and novel causes. Curr Opin Endocrinol Diabetes Obes. 2009;16:446–450. - PubMed
    1. Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, et al. Recurrent implantation failure: definition and management. Reprod BioMed Online. 2014;28:14–38. - PubMed
    1. Polanski LT, Baumgarten MN, Quenby S, Brosens J, Campbell BK, Raine-Fenning NJ. What exactly do we mean by ‘recurrent implantation failure’? A systematic review and opinion. Reprod BioMed Online. 2014;28:409–423. - PubMed

LinkOut - more resources