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Review
. 2015 Apr;13(4):195-202.

Granulocyte colony-stimulating factor and reproductive medicine: A review

Marcelo Borges Cavalcante  1 , Fabrício DA Silva Costa  2 , Ricardo Barini  3 , E Araujo Júnior  4
Affiliations
Review

Granulocyte colony-stimulating factor and reproductive medicine: A review

Marcelo Borges Cavalcante et al. Iran J Reprod Med. 2015 Apr.

Abstract

Background: Recently, the use of granulocyte colony-stimulating factor (G-CSF) has been proposed to improve pregnancy outcomes in reproductive medicine.

Objective: A systematic review of the current use of G-CSF in patients who have difficulty conceiving and maintaining pregnancy was performed.

Materials and methods: Two electronic databases (PubMed/ Medline and Scopus) were searched. Study selection, data extraction and quality assessment were performed in duplicate. The subject codes used were granulocyte colony-stimulating factor, G-CSF, recurrent miscarriage, IVF failure, and endometrium.

Results: The search of electronic databases resulted in 215 citations (PubMed/ Medline: 139 and Scopus: 76), of which 38 were present in both databases. Of the remaining 177 publications, seven studies were included in the present review.

Conclusion: Treatment with G-CSF is a novel proposal for immune therapy in patients with recurrent miscarriage and implantation failure following cycles of IVF. However, a larger number of well-designed studies are required for this treatment to be established.

Keywords: Granulocyte colony-stimulating factor; Immunotherapy; Recurrent miscarriage; Reproductive medicine; Review.

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Figure 1
Flowchart outlining the database search
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