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Review
. 2015 Apr 15;8(4):4787-94.
eCollection 2015.

The NLRP3 inflammasome and stroke

Yeqing Tong  1 , Zhi-Hong Ding  2 , Fa-Xian Zhan  3 , Li Cai  4 , Xiaoxv Yin  5 , Jin-Lian Ling  6 , Jian-Jun Ye  3 , Shuang-Yi Hou  3 , Zuxun Lu  5 , Zhi-Hong Wang  7 , Jia-Fa Liu  3
Affiliations
Review

The NLRP3 inflammasome and stroke

Yeqing Tong et al. Int J Clin Exp Med. .

Abstract

Inflammasome pattern recognition receptors, which belong to the family of multi-meric proteins, play an important role in innate immunity, including NLRPs, NLRC, and NAIP. Among these receptors, NLRP3 (nucleotide-binding domain (NOD)-like receptor protein 3) inflammasome may activate the inflammation and participate in atherosclerosis, pathophysiology of myocardial infarction, resultin ischemia/reperfusion injury and stroke and other cardiovascular diseases. Effective regulation of NLRP3 may help prevent or even treat stroke. In recent years, the role of inflammation in stroke has attracted much attention, and the in-depth study of its mechanism of action is gradually clear. This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of stroke, which may supply some clues for future therapies and novel drug targets for stroke.

Keywords: NLRP3; inflammasome; inflammation; stroke.

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Figures

Figure 1
Figure 1
The structure of NLRP3; Apoptosis speck protein (ASC); Pyrin domains (PYD); Caspase activation and recruitment domain (CARD); NACHT domain (NACHT); Leucine-rich repeats (LRRs).
Figure 2
Figure 2
The pathways for NLRP3inflammasome activation.
See this image and copyright information in PMC

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