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. 2015 Apr 15;8(4):5949-53.
eCollection 2015.

Osteoporosis biomarkers act as predictors for diagnosis of chronic renal insufficiency in elder patients

Zhong-Xin Li  1 , Chen Xu  1 , Yan-Chun Li  1 , Qian-Mei Sun  2
Affiliations

Osteoporosis biomarkers act as predictors for diagnosis of chronic renal insufficiency in elder patients

Zhong-Xin Li et al. Int J Clin Exp Med. .

Abstract

Chronic renal insufficiency and osteoporosis have become very common among old people in China. Hyperparathyroidism caused by renal insufficiency would result in turbulence of bone metabolism and unbalance between serum calcium and phosphorus. The aim of this study is to investigate the BMD, PTH, CT and 25(OH)-Vit's significance for screening and diagnosing chronic renal insufficiency. In this study, seventy cases with chronic renal insufficiency from Jun. 2010 to Oct. 2013 were selected as the observation group. Meanwhile, another 70 volunteers with normal renal functions were set as the control group. The level of BMD, PTH, CT and 25(OH)-Vit were detected by using ELISA assay. DPX bone density meters (UNIGAMMA X-RAY PLUS) were used for the detection of BMD. The results indicated that BMD levels of the proximal femur (include Troch, Shaft, Total, Neck, Ward) and lumbar vertebra in the observation group were significantly lower while the PTH and CT were significantly higher compared with the control group (P<0.05). A positive correlation was identified between the serum creatinine (Scr) concentrations and CT, PTH, while the correlation with 25(OH)-Vit was considered to be negative. In conclusion, the BMD, PTH, CT, and 25 (OH)-Vit would provide reference in diagnosing and treatment for chronic renal insufficiency. These indexes would be important clinical significance for screening and early diagnose of osteoporosis in these patients.

Keywords: Chronic renal insufficiency; bone mineral density; correlation; influence factors; progress.

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Figures

Figure 1
Figure 1
BMD levels in all parts of proximal femur and lumbar vertebra. The different values of observation group compared with the control group were illustrated in figure.
Figure 2
Figure 2
The Cr level, PTH level and CT level in control and observation group. A. The Cr level; B. The PTH level; C. The Ct level. The different values of observation group compared with the control group were illustrated in figure.
See this image and copyright information in PMC

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