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Case Reports
. 2015 Jul;35(4):469-71.
doi: 10.3343/alm.2015.35.4.469. Epub 2015 May 21.

Identification of Mixed Lineage Leukemia Gene (MLL)/MLLT10 Fusion Transcripts by Reverse Transcription-PCR and Sequencing in a Case of AML With a FISH-Negative Cryptic MLL Rearrangement

Kiwoong Ko  1 , Min-Jung Kwon  1 , Hee-Yeon Woo  1 , Hyosoon Park  1 , Chang-Hun Park  2 , Seung-Tae Lee  2 , Sun-Hee Kim  2
Affiliations
Case Reports

Identification of Mixed Lineage Leukemia Gene (MLL)/MLLT10 Fusion Transcripts by Reverse Transcription-PCR and Sequencing in a Case of AML With a FISH-Negative Cryptic MLL Rearrangement

Kiwoong Ko et al. Ann Lab Med. 2015 Jul.
No abstract available

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Conflict of interest statement

Authors' Disclosures of Potential Conflicts of Interest: No potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1. Bone marrow karyotype showing derivative chromosomes 10 and 12 with an apparently normal chromosome 11. Karyotype: 46,XY,der(10)t(10;21)(p12;q21),der(12)del(12)(p11.2)add(12)(q24.2)[17]/46,XY[3].
Fig. 2
Fig. 2. Two fusion signals (2F) with no MLL break-apart signals. LSI MLL (B-A) probe: LSI MLL dual-color, break-apart rearrangement probe.
Abbreviation: MLL, mixed lineage leukemia gene.
Fig. 3
Fig. 3. Identification of the MLL/MLLT10 fusion transcript in acute myeloid leukemia. Sequencing analyses confirmed that the transcript was from MLL (exon 8)-MLLT10 (exon 16) rearrangement.
Abbreviation: MLL, mixed lineage leukemia gene.
See this image and copyright information in PMC

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