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. 2015 Jun;41(3):119-23.
doi: 10.5125/jkaoms.2015.41.3.119. Epub 2015 Jun 23.

Effects of fresh mineralized dentin and cementum on socket healing: a preliminary study in dogs

Mahdi Kadkhodazadeh  1 , Majid Ghasemianpour  2 , Negar Soltanian  3 , Gholam Reza Sultanian  4 , Shahriar Ahmadpour  5 , Reza Amid  1
Affiliations

Effects of fresh mineralized dentin and cementum on socket healing: a preliminary study in dogs

Mahdi Kadkhodazadeh et al. J Korean Assoc Oral Maxillofac Surg. 2015 Jun.

Abstract

Objectives: Dentin is composed of many minerals and growth factors. Based on this composition, we studied its effect as a possible regenerative material for alveolar healing.

Materials and methods: This study was conducted using four 2.5-year-old mongrel dogs (male; weight, 25 to 30 kg). The third mandibular premolars were carefully mobilized with a dental elevator and then removed using forceps. The crown portions of the extracted teeth were removed with cutters, and the root portions of the remaining teeth were collectively trimmed as closely as possible to 350 to 500 µm. Dentin and cementum (DC) chips harvested from the extracted teeth were soaked in blood and packed into the fresh sockets (autograft). Biopsies were performed at the ends of day 14 and day 56 following implantation. Data were expressed as mean±standard deviation and compared with t-test results.

Results: The ratio of SA(bone) to total area of each probe was determined and was 170±16 µm(2) for the control group and 71±14 µm(2) for the DC group, a significant difference (P<0.05).

Conclusion: DC particulate grafts offered no improvement in bone regeneration in alveolar extraction sockets.

Keywords: Cementum; Dentin; Healing; Tooth extraction.

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Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. A stereological counting frame was superimposed on each randomized field. This frame is composed of 30 squares (each square, 25 µm). ×40.
Fig. 2
Fig. 2. Dentin/cementum particle (asterisk) and a blood vessel (arrow) in an alveolar socket at the end of the second week. H&E staining, ×40.
Fig. 3
Fig. 3. New bone formation (arrowhead), particles of dentin/cementum (arrow) in the periphery, and newly formed bone adjacent to the particles at the end of the eighth week. H&E staining, ×20.
Fig. 4
Fig. 4. Bone formed in a centripetal pattern. Bone spicules (arrowhead), connective tissue (asterisk) and a blood vessel (arrow) in the control group at the eighth week. H&E staining, ×20.
Fig. 5
Fig. 5. Red blood cells, venules (arrowhead), and connective tissue (asterisk) in the control group at the eighth week. H&E staining, ×20.
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