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Review
. 2015 Jun;104(6):502-6.
doi: 10.5935/abc.20150025. Epub 2015 Mar 27.

Reverse Cardiac Remodeling: A Marker of Better Prognosis in Heart Failure

[Article in English, Portuguese]
José Rosino de Araújo Rocha Reis Filho  1 , Juliano Novaes Cardoso  1 , Cristina Martins dos Reis Cardoso  1 , Antonio Carlos Pereira-Barretto  1
Affiliations
Review

Reverse Cardiac Remodeling: A Marker of Better Prognosis in Heart Failure

[Article in English, Portuguese]
José Rosino de Araújo Rocha Reis Filho et al. Arq Bras Cardiol. 2015 Jun.

Abstract

In heart failure syndrome, myocardial dysfunction causes an increase in neurohormonal activity, which is an adaptive and compensatory mechanism in response to the reduction in cardiac output. Neurohormonal activity is initially stimulated in an attempt to maintain compensation; however, when it remains increased, it contributes to the intensification of clinical manifestations and myocardial damage. Cardiac remodeling comprises changes in ventricular volume as well as the thickness and shape of the myocardial wall. With optimized treatment, such remodeling can be reversed, causing gradual improvement in cardiac function and consequently improved prognosis.

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Conflict of interest statement

Potential Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
ACE inhibitors prevent cardiac dilation and beta-blockers reverse it. Coh JN et al JACC 2000; 35: 569-82.
Figure 2
Figure 2
Beta-blockers used at the correct dosage reverses cardiac dilation; this reduction is already evident at 3 months of treatment. Melo D et al. JACC 2011; 57 (supl A): 17.
See this image and copyright information in PMC

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