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. 2015 Jul 2;10(7):e0131804.
doi: 10.1371/journal.pone.0131804. eCollection 2015.

Assessment of Allergy to Milk, Egg, Cod, and Wheat in Swedish Schoolchildren: A Population Based Cohort Study

Anna Winberg  1 , Christina E West  1 , Åsa Strinnholm  2 , Lisbeth Nordström  1 , Linnea Hedman  2 , Eva Rönmark  2
Affiliations

Assessment of Allergy to Milk, Egg, Cod, and Wheat in Swedish Schoolchildren: A Population Based Cohort Study

Anna Winberg et al. PLoS One. .

Abstract

Objectives: Knowledge about the prevalence of allergies to foods in childhood and adolescence is incomplete. The purpose of this study was to investigate the prevalence of allergies to milk, egg, cod, and wheat using reported data, clinical examinations, and double-blind placebo-controlled food challenges, and to describe the phenotypes of reported food hypersensitivity in a cohort of Swedish schoolchildren.

Methods: In a population-based cohort of 12-year-old children, the parents of 2612 (96% of invited) completed a questionnaire. Specific IgE antibodies to foods were analyzed in a random sample (n=695). Children reporting complete avoidance of milk, egg, cod, or wheat due to perceived hypersensitivity and without physician-diagnosed celiac disease were invited to undergo clinical examination that included specific IgE testing, a celiac screening test, and categorization into phenotypes of food hypersensitivity according to preset criteria. Children with possible food allergy were further evaluated with double-blind challenges.

Results: In this cohort, the prevalence of reported food allergy to milk, egg, cod, or wheat was 4.8%. Food allergy was diagnosed in 1.4% of the children after clinical evaluation and in 0.6% following double-blind placebo-controlled food challenge. After clinical examination, children who completely avoided one or more essential foods due to perceived food hypersensitivity were categorized with the following phenotypes: allergy (29%), outgrown allergy (19%), lactose intolerance (40%), and unclear (12%).

Conclusions: There was a high discrepancy in the prevalence of allergy to milk, egg, cod and wheat as assessed by reported data, clinical evaluation, and double-blind food challenges. Food hypersensitivity phenotyping according to preset criteria was helpful for identifying children with food allergy.

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Conflict of interest statement

Competing Interests: One of the sponsors, ThermoFisher Diagnostics, provided materials for part of the IgE testing and for the transglutaminase A analyses but had no involvement in data interpretation, in writing the report, or in the decision to submit the paper for publication. This does not alter the authors’ adherence to PLOS One policies on sharing data and materials.

Figures

Fig 1
Fig 1. Study overview.
See this image and copyright information in PMC

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