Heterotopic Ossification: Basic-Science Principles and Clinical Correlates
- PMID: 26135077
- PMCID: PMC6948799
- DOI: 10.2106/JBJS.N.01056
Heterotopic Ossification: Basic-Science Principles and Clinical Correlates
Erratum in
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Erratum.J Bone Joint Surg Am. 2015 Sep 2;97(17):e59. doi: 10.2106/JBJS.O.e59. J Bone Joint Surg Am. 2015. PMID: 26333744 Free PMC article. No abstract available.
Abstract
➤ Heterotopic ossification occurs most commonly after joint arthroplasty, spinal cord injury, traumatic brain injury, blast trauma, elbow and acetabular fractures, and thermal injury.➤ The conversion of progenitor cells to osteogenic precursor cells as a result of cell-mediated interactions with the local tissue environment is affected by oxygen tension, pH, availability of micronutrients, and mechanical stimuli, and leads to heterotopic ossification.➤ Radiation and certain nonsteroidal anti-inflammatory medications are important methods of prophylaxis against heterotopic ossification.➤ Well-planned surgical excision can improve patient outcomes regardless of the joint involved or the initial cause of injury.➤ Future therapeutic strategies are focused on targeted inhibition of local factors and signaling pathways that catalyze ectopic bone formation.
Copyright © 2015 by The Journal of Bone and Joint Surgery, Incorporated.
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